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RIFAMPICIN [RIF]

Rv0667

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ID	SeqNo	Primary reference	Polymorphism	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations
939	1	Heep M AAC 2000	GTC/TTC	146	Val/Phe	Published 2003	Japan	Sequencing	Whole gene	R	1-4, 8-32 ug/ml	N.S.	(6/6 \|\| 3 high level of resistance / 6 total)	(3/0)
2202	1	Heep M AAC 2000	GTC/TTC	146	Val/Phe	Published 2003	Japan	Sequencing	Whole gene	R	1-4, 8-32 ug/ml	N.S.	(6/6 \|\| 3 high level of resistance / 6 total)	(3/0)
940	2	Taniguchi H FEMS Micro 1996	GCG/GTG	381	Ala/Val	Published 1997	Japan	Sequencing	Whole gene	R	200 ug/ml	Proportion method, absolute concentration method	21/39	(1/0)
941	3	Cavusoglu C JCM 2002	CAG/CAT	490	Gln/His	Published 2002	Turkey	Line probe assay, Sequencing	RRDR	R, RE, RHE, RH, RHES, RHS	N.S.	Proportion method	41/41	(1/0)
942	4	Schilke K IntJTubLungDis 1999	GAG/GCG	504	Glu/Ala	Published 1999	South Africa	Sequencing	RRDR	MDR	N.S.	Not specified	105/105	(2/0)	Double mutation with 531
943	5	Heym B Lancet 1994	TTC/TTG	505	Phe /Leu	1991-1992	La Reunion	PCR-SSCP		RSHE	> 100 mg/L	Proportion method	13/39	(2/0)	1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present
944	6	Stavrum R PlosOne 2009	TTC/TTA	505	Phe /Leu	Published 2009	India	Sequencing	Whole gene	RSHE	> 100 mg/L	Proportion method	13/39	(2/0)	1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present
945	7	Wang Q JProtRes 2007	TTC/TCC	505	Phe/Ser	Published 1997	China	Sequencing	Whole gene	R	N.S.	Proportion method, absolute concentration method	112/30	1/0
946	8	Bahrmand AR JCM 2009	GGC/AGC	507	Gly/Ser	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	<50 ug/ml	Proportion method	41/286	1/0	rpoB T508P
947	9	Kim BJ JCM 1997	GGC/GAC	507	Gly/Asp	Published 1997	South Korea	PCR-SSCP, Sequencing	RRDR	R	N.S.	Absolute concentration method.	32/58	1/0	Location of double mutants not specified.
948	10	Bahrmand AR JCM 2009	GGC/GAT	507	Gly/Asp	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	2/0	rpoB Q513STOP, H526Y, S531F
949	11	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del GGC ACC	507-508	del Gly Thr
950	12	Bahrmand AR JCM 2009	ACC/CAC	508	Thr/His	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	6/0	rpoB H526Q, S531F
951	13	Bahrmand AR JCM 2009	ACC/CCC	508	Thr/Pro	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	<50 ug/ml	Proportion method	41/286	4/0	rpoB G507S
952	14	Bahrmand AR JCM 2009	ACC/GCC	508	Thr/Ala	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	<75 ug/ml	Proportion method	41/286	2/0	rpoB G523A
953	15	Mani C JCM 2001	ACC/AGC	508	Thr/Ser	Published 2001	India	Sequencing	RRDR	R	>128ug/ml	Proportion method	44/50	1/0	None described in the region sequenced.
954	16	Matsiota-Bernard P JCM 1998	ACC/GCT	508	Thr/Ser	1995-1996	Greece	Line probe assay, Sequencing	RRDR	RHSEth	N.S.	Proportion method	17/17	1/0	None described in the region sequenced.
955	17	Zenteno-Cuevas R MemInstOswaldCruz 2009	AGC/CAG	509	Ser/Gln	2007	Mexico	Sequencing	RRDR	HRSEZ	N.S.	BACTEC 460	15/25	1/0	None
956	18	Williams D AAC 1994	AGC/ACC	509	Ser/Thr	Published 1994	Canada	Sequencing	RRDR	RHES	N.S.	Proportion method	108/120	(1/0)	Double mutation with 526 (Asp)
957	19	Sekiguchi J JCM 2007 Jan	AGC/AGG	509	Ser/Arg	Published 2007	Japan	Sequencing	RRDR	R, MDR	N.S.	Proportion method, BACTEC	28/138	(0/1)
958	20	Zenteno-Cuevas R MemInstOswaldCruz 2009	CAG/AAG	510	Gln/Lys	2007	Mexico	Sequencing	RRDR	HREZ	N.S.	BACTEC 460	15/25	1/0	None
959	21	Sajduda A JCM 2004	CAG/CAC	510	Gln/His	2000	Poland	real-time sequencing FRET	RRDR	R, MDR	N.S.	BACTEC 460	64/113	(2/0)	rpoB: double mutation with 516 GAC/TAC
960	22	Kapur V JCM 1994	CTG/CCG	511	Leu/Pro	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	4/0	One of the strains was also Asp441Glu; another was Asp441Tyr; the third was also Ser437Thr.
961	23	Kapur V JCM 1994	CTG/CGG	511	Leu/Arg	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	None described in the region sequenced.
962	24	Siddiqi N AAC 2002	CTG/GTG	511	Leu/Val	1995-1998	India	Sequencing	RRDR	R,O	Not listed in Table	Proportion method	94/126	(2/0)	1) rpoB dual mutation with N518T; gyrA S95T; 2) gyrA S95T
963	25	Kapur V JCM 1994	AGC/ACC	512	Ser/Thr	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	Also mutated at Leu436Pro.
964	26	Sajduda A JCM 2004	AGC/ATC	512	Ser/Ile	2001	Poland	real-time sequencing FRET	RRDR	R, MDR	N.S.	BACTEC 460	64/113	(1/0)	rpoB: double mutation with 516 GAC/GGC
965	27	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	AGC/CGC	512	Ser/Arg
966	28	Chan RCY JAC 2007	AGC/GGC	512	Ser/Gly	1994-2004	Hong Kong	PCR-SSCP, Sequencing	RRDR			Absolute concentration method	250	221
967	29	Bahrmand AR JCM 2009	CAA/TAA	513	Gln/STOP	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	2/0	rpoB G507D, H526Y, S531F
968	30	Bahrmand AR JCM 2009	CAA/AAT	513	Gly/Asn	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	2/0	rpoB S512T, H526F, S531L
969	31	Kapur V JCM 1994	CAA/CTA	513	Gln/Leu	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	None described in the region sequenced.
970	32	Kapur V JCM 1994	CAA/AAA	513	Gln/Lys	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	None described in the region sequenced.
971	33	Prammananan T CMI 2008	CAA/GAA	513	Gln/Glu	2003-2005	Thailand	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	154/113	1/0	None described in the region sequenced.
972	34	Kim BJ JCM 1997	CAA/CCA	513	Gln/Pro	Published 1997	South Korea	Sequencing	RRDR	R	N.S.	Absolute concentration method.	32/58	2/0	Location of double mutants not specified.
973	35	Valim A JCM 2000	CAA/CAC	513	Gln/His								82/100	1/0
974	36	Secondary Publication: O'Sullivan DM JAntiChemo 2005	CAA/CGA	513	Gln/Arg
975	37	Kapur V JCM 1994	ins TTC	513-514	ins Phe	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	None described in the region sequenced.
976	38	Kapur V JCM 1994	ins TTC ATG	513-514	ins Phe Met	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	None described in the region sequenced.
977	39	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del CAA TTC	513-514	del Gln Phe
978	40	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del AA TTC ATG G	513-516	Gln/His and del Phe Met
979	41	Valim A JCM 2000	del TTC	514	del Phe	1996-1998	Brazil	Sequencing	RRDR	RHSZEth	N.S.	Proportion method	82/100	(1/0)	Same isolate had deletions: 515 (ATG-Met), 516(GAC-Asp) and change in codon 513 CAA(Gln)/CAC(His)
980	42	Taniguchi H FEMS Micro 1996	TTC/TTG	514	Phe/Leu	Published 1996	Japan	Sequencing	Whole gene	R	12.5 ug/ml	Proportion method, absolute concentration method	21/39	(1/0)
981	43	Valim A JCM 2000	TTC/GTC	514	Phe/Val	1996-1998	Brazil	Sequencing	RRDR	RHSZEth	N.S.	Proportion method	82/100	(1/0)	Same isolate had change in codon 531 TCG(Ser)/TTG(Leu)
982	44	Cavusoglu C JCM 2002	ins CGG	514-515	ins Arg	Published 2002	Turkey	Line probe assay, Sequencing	RRDR	R, RE, RHE, RH, RHES, RHS	N.S.	Proportion method	41/41	(1/0)
983	45	Lipin MY CMI 2007	del C AT	514-515	Phe/Leu and del Met	1998-2001	Russia	Sequencing	RRDR	RHS, RHSK, RHSE	N.S.	Absolute concentration method.	217/217	1/0	None described in the region sequenced.
984	46	Valim A JCM 2000	del TTC ATG GAC	514-516	del Phe Met Asp	1996-1998	Brazil	Sequencing	RRDR	RHSZEth	N.S.	Proportion method	82/100	(1/0)	Same isolate had change in codon 513 CAA(Gln)/CAC(His)
985	47	Hillemann D Int J Tuberc Lung Dis 2005	ins TTC	515	ins Phe	2004	Kazakhstan, Germany	real-time sequencing FRET	RRDR	MDR	N.S.	N.S.	92/152	(1/0)
986	48	Sajduda A JCM 2004	ATG/ATT	515	Met/Ile	2003	Poland	real-time sequencing FRET	RRDR	R, MDR	N.S.	BACTEC 460	64/113	(8/0)	rpoB: double mutation with 516 GAC/TAC
987	49	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	ATG/ATA	515	Met/Ile
988	50	Valim A JCM 2000	del ATG GAC CAG AAC	515-518	del Met Asp Gln Asn	1996-1998	Brazil	Sequencing	RRDR	RHSEZEth	N.S.	Proportion method	82/100	(1/0)
989	51	Schilke K IntJTubLungDis 1999	GAC/AAC	516	Asp/Asn	Published 1999	South Africa	Sequencing	RRDR	MDR	N.S.	N.S.	105/105	(1/0)
990	52	Bahrmand AR JCM 2009	GAC/CAC	516	Asp/His	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	50-75 ug/ml	Proportion method	41/286	3/0	rpoB D516H, H526R
991	53	Kapur V JCM 1994	GAC/GTC	516	Asp/Val	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	None described in the region sequenced.
992	54	Kapur V JCM 1994	GAC/GAG	516	Asp/Glu	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	Also mutated at Leu436Pro.
993	55	Hillemann D Int J Tuberc Lung Dis 2005	GAC/GGC	516	Asp/Gly	2004	Kazakhstan, Germany	real-time sequencing FRET	RRDR	MDR	N.S.	N.S.	92/152	(1/0)
994	56	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	GAC/GCC	516	Asp/Ala
995	57	Sajduda A JCM 2004	GAC/GTG	516	Asp/Val	2004	Poland	real-time sequencing FRET	RRDR	R, MDR	N.S.	BACTEC 460	64/113	(1/0)	None
996	58	Kapur V JCM 1994	GAC/TAC	516	Asp/Tyr	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	Also mutated at Leu436Pro.
997	59	Hillemann D Int J Tuberc Lung Dis 2005	GAC/TTC	516	Asp/Phe	2004	Kazakhstan, Germany	real-time sequencing FRET	RRDR	MDR	N.S.	N.S.	92/152	(1/0)
998	60	Kapur V JCM 1994	del GAC CAG	516-517	del Asp Gln	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	None described in the region sequenced.
999	61	Xueqiong W MolBiotech 2009	GAC/CAC	517	Gln/His	2002-2005	China	Sequencing	RRDR	RSE	N.S.	Absolute concentration method	112/148	1/0	rpoB N518D
1000	62	Mani C JCM 2001	del GAC	517	del Gln	Published 2001	India	Sequencing	RRDR	R	>128ug/ml	Proportion method	44/50	1/0	None described in the region sequenced.
1001	63	Sajduda A JCM 2004	CAA/CTA	517	Gln/Leu	2005	Poland	real-time sequencing FRET	RRDR	R, MDR	N.S.	BACTEC 460	64/113	(1/0)	None
1002	64	Hillemann D AAC 2005	del CAG AAC	517-518	del Gln Asn	2001	Germany	real-time sequencing	RRDR	MDR	N.S.		103/113	(1/0)	katG 315 AGC-ACC/Ser-Thr
1003	65	Kapur V JCM 1994	del CAG AAC	517-518	del Gln Asn	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	None described in the region sequenced.
1004	66	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del G AAC AA	517-519	Gln/His and del Asn Asn
1005	67	Wang Q JProtRes 2007	AAC/TAC	518	Asn/Tyr	Published 1997	China	Sequencing	Whole gene	R	N.S.	Proportion method, absolute concentration method	112/30	1/0
1006	68	Siddiqi N AAC 2002	AAC/ACC	518	Asn/Thr	1995-1998	India	Sequencing	RRDR	RHO, ROS, RO, RH	N.S.	Proportion method	94/126	(6/0)	1) rpoB dual mutaton with L511L; katG and inhA NM; gyrA A90A, S95T 3) rpoB dual mutation with R528P; gyrA S95T; rpsL NM; 4) rpoB dual mutaton with L511V; gyrA S95T; 5) gyrA S95T; 6) gyrA NM; 7) rpoB dual mutation with D516V; katG and inhA R463L
1007	69	Hillemann D AAC 2005	AAC/ATC	518	Asn/Ile	2001	Germany	real-time sequencing	RRDR	MDR	N.S.		103/113	(1/0)	None
1008	70	Kim BJ JCM 1997	AAC/CAC	518	Asn/His	Published 1997	South Korea	Sequencing and PCR-SSCP	RRDR	R	N.S.	Absolute concentration method.	32/58	1/0	Location of double mutants not specified.
1009	71	Chan RCY JAC 2007	AAC/GAC	518	Asn/Asp	1994-2004	Hong Kong	PCR-SSCP, Sequencing	RRDR			Absolute concentration method.	250	221
1010	72	Bahrmand AR JCM 2009	AAC/AAG	519	Asn/Lys	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	50 ug/ml	Proportion method	41/286	2/0	rpoB L511V, Q513E, H526R
1011	73	Heym B Lancet 1994	del AAC	519	del Asn	1991-1992	Russia, Netherlands	PCR-SSCP		MDR	10-100ug/ml	Proportion method	13/39	(2/0)	1) katG mutation present; inhA no mutation present; 2) katG no mutation present
1012	74	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CTG/ATG	521	Leu/Met
1013	75	Taniguchi H FEMS Micro 1996	CTG/CCG	521	Leu/Pro	Published 1998	Japan	Sequencing	Whole gene	R	< 0.39 ug/ml	Proportion method, absolute concentration method	21/39	(0/1)
1014	76	Secondary Publication: O'Sullivan DM JAntiChemo 2005	CTG/CTA	521	Leu/Leu
1015	77	Bodmer T JAC 1995	TCG/TTG	522	Ser/Leu	Published 1998	N.S.	PCR-SSCP	RRDR	R	8ug/ml	BACTEC 460	26/36	(1/0)
1016	78	Yuen LK JCM 1999	TCG/CAG	522	Ser/Gln	1990-1997	Timor	Sequencing	RRDR	RH	32-256 ug/ml	Resistance ratio method, ,BACTEC 460, E-test	33/50	(2/0)	None
1017	79	Secondary Publication: O'Sullivan DM JAntiChemo 2005	TCG/TGG	522	Ser/Trp
1018	80	El Baghdadi J IJTLD 2003	CCC/ACC	523	Gly/Trp	1996-2001	Morocco	Sequencing	RRDR	RHS	N.S.	Resistance ratio method	101/122	(1/0)
1019	81	Pozzi G JCM 1999	GGG/TGG	523	Gly/Trp	Published April 2000	Italy	Sequencing	RRDR	RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ	8-128ug/ml	Absolute concentration method	37/37	(1/0)	Triple mutation with GAC516TAC and ACC525ATC
1020	82	Bahrmand AR JCM 2009	GGG/GCG	523	Gly/Ala	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	25/0	rpoB T508A or S531L or L511V, or H526R
1021	83	Valim A JCM 2000	TTG/TGG	524	Leu/Trp	1996-1998	Brazil	Sequencing	RRDR	MDR	N.S.	Proportion method	82/100	(1/0)	Same isolate had changes in codons 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)
1022	84	Zenteno-Cuevas R MemInstOswaldCruz 2009	TTG/TCG	524	Leu/Ser	2007	Mexico	Sequencing	RRDR	HR	N.S.	BACTEC 460	15/25	1/0	rpoB S531L
1023	85	Valim A JCM 2000	ACC/CCC	525	Thr/Pro	1996-1998	Brazil	Sequencing	RRDR	MDR	N.S.	Proportion method	82/100	(1/0)	Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)
1024	86	Pozzi G JCM 1999	ACC/ATC	525	Thr/Ile	Published April 2001	Italy	Sequencing	RRDR	RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ	8-128ug/ml	Proportion method	37/37	(1/0)	Triple mutation with GAC516TAC and GGG523TGG
1025	87	Bahrmand AR JCM 2009	CAC/TTC	526	His/Phe	2005-2006	Iran	Sequencing	411bp fragment of rpoB	41R, 37MDR	>100 ug/ml	Proportion method	41/286	2/0	rpoB S512T, G513N, S531L
1026	88	Ramaswamy SV J Med Micro 2004	CAC/AAC	526	His/Asn	1996-2001	Mexico	Sequencing		RHSE	N.S.	Proportion method	37/50	(1/0)	rpoB: Double mutation with 435 GAC/GAG; embB: 306 ATG/ATA1
1027	89	Kapur V JCM 1994	CAC/GAC	526	His/Asp	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	8/0	None described in the region sequenced.
1028	90	Kapur V JCM 1994	CAC/TAC	526	His/Tyr	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	39/0	None described in the region sequenced.
1029	91	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CAC/ACC	526	His/Thr
1030	92	Prammananan T CMI 2008	CAC/AGC	526	His/Ser	2003-2005	Thailand	Sequencing	Whole gene	MDR	N.S.	Proportion method	154/113	1/0	rpoB 515 ATG/CTG
1031	93	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CAC/GGC	526	His/Gly
1032	94	Kim BJ JCM 1997	CAC/TGC	526	His/Cys	Published 1997	South Korea	PCR-SSCP, Sequencing	RRDR	R	N.S.	Absolute concentration method.	32/58	2/0	Location of double mutants not specified.
1033	95	Kim BJ JCM 1997	CAC/CGC	526	His/Arg	Published 1997	South Korea	PCR-SSCP, Sequencing	RRDR	R	N.S.	Absolute concentration method.	32/58	1/0	Location of double mutants not specified.
1034	96	Bodmer T JAC 1995	CAC/CCC	526	His/Pro	Published 2001	N.S.	PCR-SSCP	RRDR	R	8ug/ml	BACTEC 460	26/36	(2/0)
1035	97	Valim A JCM 2000	CAC/CTG	526	His/Leu	1996-1998	Brazil	Sequencing	RRDR	RHSEZEth	N.S.	Proportion method	82/100	(1/0)	Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 527 del AAG(Lys)
1036	98	Sheng J JApplMicro 2008	CAC/CTT	526	His/Leu	2002-2003	China	PCR-SSCP , Sequencing	RRDR	R	N.S.	Agar proportion method	49/56	1/0	None in rpoB
1037	99	Kapur V JCM 1994	CAC/CTC	526	His/Leu	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	2/0	None described in the region sequenced.
1038	100	Kapur V JCM 1994	CAC/CAA	526	His/Gln	Published 1994	USA	Sequencing	Whole gene	R	N.S.	Proportion method, BACTEC	121/128	1/0	Also mutated at Ser456Cys.
1039	101	Bodmer T JAC 1995	CAC/CAG	526	His/Gln	Published 2003	N.S.	PCR-SSCP	RRDR	R	>8ug/ml	BACTEC 460	26/36	(2/0)	Double mutation with 498 Val/Ala
1040	102	Siddiqi N AAC 2002	AAG/AAT	527	Lys/Asn	1995-1998	India	Sequencing	RRDR	HRH	40 ug/ml	Proportion method	94/126	(2/0)	1) katG or inhA R463L; 2) katG or inhA R463L, rpoB dual mutation with L521L
1041	103	Valim A JCM 2000	del AAG	527	del Lys	1996-1998	Brazil	Sequencing	RRDR	RHSEZEth	N.S.	Proportion method	82/100	(1/0)	Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu)
1042	104	Williams D AAC 1994	AAG/CAG	527	Lys/Gln	Published 1995	USA	PCR-HDF, Sequencing	RRDR	RHEEt	N.S.	Proportion method	108/120	(1/0)	Double mutation with 526 (His)
1043	105	Siddiqi N AAC 2002	CGC/CAC	528	Arg/His	1995-1998	India	Sequencing	RRDR	HR, ROS	64-128 ug/ml	Proportion method	94/126	(2/0)	1) rpoB dual mutation with H526Y; gyrA S95T; rpsL NM; 2) rpoB 1 dual mutation with with S531W; katG and inhA R463L, Inh (C/T)
1044	106	Siddiqi N AAC 2002	CGC/CCC	528	Arg/Pro	1995-1998	India	Sequencing	RRDR	ROS, RHO, RHS, RH	40-64 ug/ml*	Proportion method	94/126	(4/0)	1) rpoB dual mutation with N518T; gyrA S95T; rpsL NM; 2) katG or inhA NA; gyrA S95T; 3) katG or inhA R463L; rpsL K121K; 4) katG or inhA R463L; rpoB dual mutation with H526Y
1045	107	Zenteno-Cuevas R MemInstOswaldCruz 2009	CGC/CCT	528	Arg/Pro	2007	Mexico	Sequencing	RRDR	HRSEZ	N.S.	BACTEC 460	15/25	1/0	None
1047	109	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	TCG/CAG	531	Ser/Gln
1048	110	Donabella V Am J Respir Cell Mol Biol 1994	TCG/TTG	531	Ser/Leu	Published 1994	USA	Sequencing	RRDR	R	N.S.		(1/9)	(1/0)
1049	111	Bodmer T JAC 1995	TCG/TGG	531	Ser/Trp	Published 2005	N.S.	PCR-SSCP	RRDR	R	8ug/ml	BACTEC 460	26/36	(1/0)
1050	112	Bodmer T JAC 1995	TCG/TAT	531	Ser/Tyr	Published 2006	N.S.	PCR-SSCP	RRDR	R	>8ug/ml	BACTEC 460	26/36	(1/0)
1051	113	Hillemann D AAC 2005	TCG/TTT	531	Ser/Phe	2001	Germany	real-time sequencing	RRDR	MDR	N.S.		103/113	(2/0)	katG 315 AGC-ACC/Ser-Thr
1052	114	Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	TCG/TGT	531	Ser/Cys
1053	115	Moghazeh SL AAC 1996	CTG/CCG	533	Leu/Pro	1992-1995	USA	Sequencing	N.S	R	>32ug/ml	Proportion method	24/24	1/0	None described in the region sequenced.
1054	116	Valim A JCM 2000	CTG/CCT	533	Leu/Pro	1996-1998	Brazil	Sequencing	RRDR	RH, RHS	N.S.	Proportion method	82/100	(2/0)	Same isolate had double mutation: 526 CAC(His)/CTG(Leu)
1055	117	Tracevska T JCM 2002	CCC/TCC	535	Pro/Ser	1999-2000	Latvia	Line probe assay, Sequencing	RRDR	R, RH	N.S.	Absolute concentration method, BACTEC	51/70	(4/0)	Double mutation with D516Y
1056	118	Prammananan T CMI 2008	CCC/CAC	535	Pro/His	2003-2005	Thailand	Sequencing	Whole gene	MDR	N.S.	Proportion method	154/113	1/0	rpoB 526 CAC/AGC His/Ser
1046	108	Wang Q JProtRes 2007	TCG/TAG	538	Leu/STOP	Published 1997	China	Sequencing	Whole gene	R	N.S.	Proportion method, absolute concentration method	112/30	1/0
1057	119	Wang Q JProtRes 2007	CTG/CCG	538	Leu/Pro	Published 1997	China	Sequencing	Whole gene	R	N.S.	Proportion method, absolute concentration method	112/30	1/0
1058	120	Prammananan T CMI 2008	GAG/GGG	541	Glu/Gly	2003-2005	Thailand	Sequencing	Whole gene	MDR	N.S.	Proportion method	154/113	1/0	rpoB 526 CAC/TAC His/Tyr
1059	121	Pozzi G JCM 1999	GAG/GAT	541	Glu/Gly	Published 2002	Italy	Sequencing	RRDR	RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ	32-128 ug/ml	Proportion method	37/37	(1/0)	Triple mutation with CAC526GAC and TCG553GCG
1060	122	Aslan G JpnJInfectDis 2008	CTG/ATG	545	Leu/Met	2003-2006	Turkey	Sequencing	RRDR	R or MDR	N.S.	BACTEC 460	19/41	3/0	rpoB S531A, katG S315T
1061	123	Pozzi G JCM 1999	TCG/GCG	553	Ser/Ala	Published 2003	Italy	Sequencing	RRDR	RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ	32-128 ug/ml	Proportion method	37/37	(1/0)	Triple mutation with CAC526GAC and GAG541GAT
1062	124	Ramaswamy SV J Med Micro 2004	ATC/GTC	561	Ile/Val	1996-1998	Mexico	Sequencing	RRDR	RHSE	N.S.	Proportion method	37/50	(1/0)	rpoB: Double mutation with 450 TCG/TTG; embB: 306 ATG/ATA
1063	125	Heep M JCM 2001	ATC/ACC	561	Ile/Thr	1997	Germany	Sequencing	RRDR	N.S.	N.S.	Proportion method	111/111	(1/0)	Double mutation with S456L
1064	126	Hauck Y JAC 2009	GAA/GGA	562	Glu/Gly	Published 2009	Various	Sequencing	RRDR	R	<1 ug/ml	MGIT 960	122/122	1/0	rpoB P564L
1065	127	Hauck Y JAC 2009	CCT/CTT	564	Pro/Leu	Published 2009	Various	Sequencing	RRDR	R	<1 ug/ml	MGIT 960	122/122	1/0	rpoB E562G
1066	128	Heep M JCM 2001	CTG/GTG	571	Leu/Val	1997	Germany	Sequencing	RRDR	RHEZ	N.S.	Proportion method	111/111	(2/0)	Double mutation with D441Y
1067	129	Yuen LK JCM 1999	ATC/TTC	572	Ile/Phe	1990-1997	Vietnam	Sequencing	RRDR	RHE	> 256 ug/ml	Resistance ratio method, BACTEC 460, E-test	33/50	(1/0)	None
1068	130	Chan RCY JAC 2007	TCG/TTG	574	Ser/Leu	1994-2004	Hong Kong	PCR-SSCP, Sequencing	RRDR	RHEZ	>64 ug/ml	Absolute concentration method.	221/250	1	katG 311 Asp/Gly
1069	131	Prammananan T CMI 2008	TCG/GCG	622	Ser/Ala	2003-2005	Thailand	Sequencing	Whole gene	MDR	N.S.	Proportion method	154/113	1/0	rpoB 531 TCG/TTG ser/Leu
1070	132	Heep M JCM 2001	CGC/TGC	633	Arg/Cys	1997	Germany	Sequencing	RRDR	RH	N.S.	Proportion method, BACTEC 460	111/111	(1/0)	Double mutation with S456L
1071	133	Heep M JCM 2001	GAG/GAT	672	Glu/Asp	1997	Germany	Sequencing	RRDR	RH, RHE, RHZ, RHEZ	N.S.	Proportion method, BACTEC 460	111/111	(7/0)	Double mutation with S456W