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RIFAMPICIN [RIF]


rpoB: Rv0667embB: Rv3795

Rv0667

More about Rv0667 on    TBDB.org

More about Rv0667 on    TubercuList

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Codons 660 to 679:1 Mutation Codons 620 to 639:2 Mutation Codons 560 to 579:7 Mutation Codons 540 to 559:4 Mutation Codons 520 to 539:46 Mutation Codons 500 to 519:70 Mutation Codons 480 to 499:1 Mutation Codons 380 to 399:1 Mutation Codons 140 to 159:2 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
9391 Heep M AAC 2000 GTC/TTC 146Val/PhePublished 2003JapanSequencingWhole geneR1-4, 8-32 ug/mlN.S.(6/6 || 3 high level of resistance / 6 total)(3/0)    
22021 Heep M AAC 2000 GTC/TTC 146Val/PhePublished 2003JapanSequencingWhole geneR1-4, 8-32 ug/mlN.S.(6/6 || 3 high level of resistance / 6 total)(3/0)    
9402 Taniguchi H FEMS Micro 1996 GCG/GTG 381Ala/ValPublished 1997JapanSequencingWhole geneR200 ug/mlProportion method, absolute concentration method21/39(1/0)    
9413 Cavusoglu C JCM 2002 CAG/CAT 490Gln/HisPublished 2002TurkeyLine probe assay, Sequencing RRDRR, RE, RHE, RH, RHES, RHSN.S.Proportion method41/41(1/0)    
9424 Schilke K IntJTubLungDis 1999 GAG/GCG 504Glu/AlaPublished 1999South AfricaSequencingRRDRMDRN.S.Not specified105/105(2/0)Double mutation with 531   
9435 Heym B Lancet 1994 TTC/TTG 505Phe /Leu1991-1992La ReunionPCR-SSCP RSHE> 100 mg/LProportion method13/39(2/0)1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present   
9446 Stavrum R PlosOne 2009 TTC/TTA 505Phe /LeuPublished 2009IndiaSequencingWhole geneRSHE> 100 mg/LProportion method13/39(2/0)1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present   
9457 Wang Q JProtRes 2007 TTC/TCC 505Phe/SerPublished 1997ChinaSequencingWhole geneRN.S.Proportion method, absolute concentration method112/301/0    
9468 Bahrmand AR JCM 2009 GGC/AGC 507Gly/Ser2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR<50 ug/mlProportion method41/2861/0rpoB T508P   
9479 Kim BJ JCM 1997 GGC/GAC 507Gly/AspPublished 1997South KoreaPCR-SSCP, SequencingRRDRRN.S.Absolute concentration method. 32/581/0Location of double mutants not specified.   
94810 Bahrmand AR JCM 2009 GGC/GAT 507Gly/Asp2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/2862/0rpoB Q513STOP, H526Y, S531F   
94911 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del GGC ACC 507-508del Gly Thr             
95012 Bahrmand AR JCM 2009 ACC/CAC 508Thr/His2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/2866/0rpoB H526Q, S531F   
95113 Bahrmand AR JCM 2009 ACC/CCC 508Thr/Pro2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR<50 ug/mlProportion method41/2864/0rpoB G507S   
95214 Bahrmand AR JCM 2009 ACC/GCC 508Thr/Ala2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR<75 ug/mlProportion method41/2862/0rpoB G523A   
95315 Mani C JCM 2001 ACC/AGC 508Thr/SerPublished 2001IndiaSequencingRRDRR>128ug/mlProportion method44/501/0None described in the region sequenced.   
95416 Matsiota-Bernard P JCM 1998 ACC/GCT 508Thr/Ser1995-1996GreeceLine probe assay, SequencingRRDRRHSEthN.S.Proportion method17/171/0None described in the region sequenced.   
95517 Zenteno-Cuevas R MemInstOswaldCruz 2009 AGC/CAG 509Ser/Gln2007MexicoSequencingRRDRHRSEZN.S.BACTEC 46015/251/0None   
95618 Williams D AAC 1994 AGC/ACC 509Ser/ThrPublished 1994CanadaSequencingRRDRRHESN.S.Proportion method108/120(1/0)Double mutation with 526 (Asp)   
95719 Sekiguchi J JCM 2007 Jan AGC/AGG 509Ser/ArgPublished 2007Japan SequencingRRDRR, MDRN.S.Proportion method, BACTEC28/138(0/1)    
95820 Zenteno-Cuevas R MemInstOswaldCruz 2009 CAG/AAG 510Gln/Lys2007MexicoSequencingRRDRHREZN.S.BACTEC 46015/251/0None   
95921 Sajduda A JCM 2004 CAG/CAC 510Gln/His2000Polandreal-time sequencing FRET RRDRR, MDRN.S.BACTEC 46064/113(2/0)rpoB: double mutation with 516 GAC/TAC   
96022 Kapur V JCM 1994 CTG/CCG 511Leu/ProPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1284/0One of the strains was also Asp441Glu; another was Asp441Tyr; the third was also Ser437Thr. High confidence details 
96123 Kapur V JCM 1994 CTG/CGG 511Leu/ArgPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0None described in the region sequenced.   
96224 Siddiqi N AAC 2002 CTG/GTG 511Leu/Val1995-1998IndiaSequencingRRDRR,ONot listed in TableProportion method94/126(2/0)1) rpoB dual mutation with N518T; gyrA S95T; 2) gyrA S95T   
96325 Kapur V JCM 1994 AGC/ACC 512Ser/ThrPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0Also mutated at Leu436Pro.   
96426 Sajduda A JCM 2004 AGC/ATC 512Ser/Ile2001Polandreal-time sequencing FRET RRDRR, MDRN.S.BACTEC 46064/113(1/0)rpoB: double mutation with 516 GAC/GGC   
96527 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/CGC 512Ser/Arg             
96628 Chan RCY JAC 2007 AGC/GGC 512Ser/Gly1994-2004Hong KongPCR-SSCP, SequencingRRDR  Absolute concentration method250221    
96729 Bahrmand AR JCM 2009 CAA/TAA 513Gln/STOP2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/2862/0rpoB G507D, H526Y, S531F   
96830 Bahrmand AR JCM 2009 CAA/AAT 513Gly/Asn2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/2862/0rpoB S512T, H526F, S531L   
96931 Kapur V JCM 1994 CAA/CTA 513Gln/LeuPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0None described in the region sequenced. High confidence details 
97032 Kapur V JCM 1994 CAA/AAA 513Gln/LysPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0None described in the region sequenced.   
97133 Prammananan T CMI 2008 CAA/GAA 513Gln/Glu2003-2005ThailandSequencingWhole geneRN.S.Proportion method, BACTEC154/1131/0None described in the region sequenced.   
97234 Kim BJ JCM 1997 CAA/CCA 513Gln/ProPublished 1997South KoreaSequencingRRDRRN.S.Absolute concentration method. 32/582/0Location of double mutants not specified.   
97335 Valim A JCM 2000 CAA/CAC 513Gln/His       82/1001/0    
97436 Secondary Publication: O'Sullivan DM JAntiChemo 2005 CAA/CGA 513Gln/Arg             
97537 Kapur V JCM 1994 ins TTC 513-514ins PhePublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0None described in the region sequenced.   
97638 Kapur V JCM 1994 ins TTC ATG 513-514ins Phe MetPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0None described in the region sequenced.   
97739 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del CAA TTC 513-514del Gln Phe             
97840 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del AA TTC ATG G 513-516Gln/His and del Phe Met             
97941 Valim A JCM 2000 del TTC 514del Phe1996-1998BrazilSequencingRRDRRHSZEthN.S.Proportion method82/100(1/0)Same isolate had deletions: 515 (ATG-Met), 516(GAC-Asp) and change in codon 513 CAA(Gln)/CAC(His)   
98042 Taniguchi H FEMS Micro 1996 TTC/TTG 514Phe/LeuPublished 1996JapanSequencingWhole geneR12.5 ug/mlProportion method, absolute concentration method21/39(1/0)    
98143 Valim A JCM 2000 TTC/GTC 514Phe/Val1996-1998BrazilSequencingRRDRRHSZEthN.S.Proportion method82/100(1/0)Same isolate had change in codon 531 TCG(Ser)/TTG(Leu)   
98244 Cavusoglu C JCM 2002 ins CGG 514-515ins ArgPublished 2002TurkeyLine probe assay, SequencingRRDRR, RE, RHE, RH, RHES, RHSN.S.Proportion method41/41(1/0)    
98345 Lipin MY CMI 2007 del C AT 514-515Phe/Leu and del Met1998-2001RussiaSequencingRRDRRHS, RHSK, RHSEN.S.Absolute concentration method. 217/2171/0None described in the region sequenced.   
98446 Valim A JCM 2000 del TTC ATG GAC 514-516del Phe Met Asp1996-1998BrazilSequencingRRDRRHSZEthN.S.Proportion method82/100(1/0)Same isolate had change in codon 513 CAA(Gln)/CAC(His)   
98547 Hillemann D Int J Tuberc Lung Dis 2005 ins TTC 515ins Phe2004Kazakhstan, Germanyreal-time sequencing FRET RRDRMDRN.S.N.S.92/152(1/0)    
98648 Sajduda A JCM 2004 ATG/ATT 515Met/Ile2003Polandreal-time sequencing FRET RRDRR, MDRN.S.BACTEC 46064/113(8/0)rpoB: double mutation with 516 GAC/TAC   
98749 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATG/ATA 515Met/Ile             
98850 Valim A JCM 2000 del ATG GAC CAG AAC 515-518del Met Asp Gln Asn1996-1998BrazilSequencingRRDRRHSEZEthN.S.Proportion method82/100(1/0)    
98951 Schilke K IntJTubLungDis 1999 GAC/AAC 516Asp/AsnPublished 1999South AfricaSequencingRRDRMDRN.S.N.S.105/105(1/0)    
99052 Bahrmand AR JCM 2009 GAC/CAC 516Asp/His2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR50-75 ug/mlProportion method41/2863/0rpoB D516H, H526R   
99153 Kapur V JCM 1994 GAC/GTC 516Asp/ValPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0None described in the region sequenced. High confidence details 
99254 Kapur V JCM 1994 GAC/GAG 516Asp/GluPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0Also mutated at Leu436Pro.   
99355 Hillemann D Int J Tuberc Lung Dis 2005 GAC/GGC 516Asp/Gly2004Kazakhstan, Germanyreal-time sequencing FRET RRDRMDRN.S.N.S.92/152(1/0)    
99456 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC 516Asp/Ala             
99557 Sajduda A JCM 2004 GAC/GTG 516Asp/Val2004Polandreal-time sequencing FRET RRDRR, MDRN.S.BACTEC 46064/113(1/0)None   
99658 Kapur V JCM 1994 GAC/TAC 516Asp/TyrPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0Also mutated at Leu436Pro. High confidence details 
99759 Hillemann D Int J Tuberc Lung Dis 2005 GAC/TTC 516Asp/Phe2004Kazakhstan, Germanyreal-time sequencing FRET RRDRMDRN.S.N.S.92/152(1/0)    
99860 Kapur V JCM 1994 del GAC CAG 516-517del Asp GlnPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0None described in the region sequenced.   
99961 Xueqiong W MolBiotech 2009 GAC/CAC 517Gln/His2002-2005ChinaSequencingRRDRRSEN.S.Absolute concentration method112/1481/0rpoB N518D   
100062 Mani C JCM 2001 del GAC 517del GlnPublished 2001IndiaSequencingRRDRR>128ug/mlProportion method44/501/0None described in the region sequenced.   
100163 Sajduda A JCM 2004 CAA/CTA 517Gln/Leu2005Polandreal-time sequencing FRETRRDRR, MDRN.S.BACTEC 46064/113(1/0)None High confidence details 
100264 Hillemann D AAC 2005 del CAG AAC 517-518del Gln Asn2001Germanyreal-time sequencingRRDRMDRN.S. 103/113(1/0)katG 315 AGC-ACC/Ser-Thr   
100365 Kapur V JCM 1994 del CAG AAC 517-518del Gln AsnPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0None described in the region sequenced.   
100466 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del G AAC AA 517-519Gln/His and del Asn Asn             
100567 Wang Q JProtRes 2007 AAC/TAC 518Asn/TyrPublished 1997ChinaSequencingWhole geneRN.S.Proportion method, absolute concentration method112/301/0    
100668 Siddiqi N AAC 2002 AAC/ACC 518Asn/Thr1995-1998IndiaSequencingRRDRRHO, ROS, RO, RHN.S.Proportion method94/126(6/0)1) rpoB dual mutaton with L511L; katG and inhA NM; gyrA A90A, S95T 3) rpoB dual mutation with R528P; gyrA S95T; rpsL NM; 4) rpoB dual mutaton with L511V; gyrA S95T; 5) gyrA S95T; 6) gyrA NM; 7) rpoB dual mutation with D516V; katG and inhA R463L   
100769 Hillemann D AAC 2005 AAC/ATC 518Asn/Ile2001Germanyreal-time sequencingRRDRMDRN.S. 103/113(1/0)None   
100870 Kim BJ JCM 1997 AAC/CAC 518Asn/HisPublished 1997South KoreaSequencing and PCR-SSCPRRDRRN.S.Absolute concentration method. 32/581/0Location of double mutants not specified.   
100971 Chan RCY JAC 2007 AAC/GAC 518Asn/Asp1994-2004Hong KongPCR-SSCP, SequencingRRDR  Absolute concentration method. 250221    
101072 Bahrmand AR JCM 2009 AAC/AAG 519Asn/Lys2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR50 ug/mlProportion method41/2862/0rpoB L511V, Q513E, H526R   
101173 Heym B Lancet 1994 del AAC 519del Asn1991-1992Russia, NetherlandsPCR-SSCP MDR10-100ug/mlProportion method13/39(2/0)1) katG mutation present; inhA no mutation present; 2) katG no mutation present   
101274 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CTG/ATG 521Leu/Met             
101375 Taniguchi H FEMS Micro 1996 CTG/CCG 521Leu/ProPublished 1998JapanSequencingWhole geneR< 0.39 ug/mlProportion method, absolute concentration method21/39(0/1)  High confidence details 
101476 Secondary Publication: O'Sullivan DM JAntiChemo 2005 CTG/CTA 521Leu/Leu             
101577 Bodmer T JAC 1995 TCG/TTG 522Ser/LeuPublished 1998N.S.PCR-SSCPRRDRR8ug/mlBACTEC 46026/36(1/0)  High confidence details 
101678 Yuen LK JCM 1999 TCG/CAG 522Ser/Gln1990-1997TimorSequencingRRDRRH32-256 ug/mlResistance ratio method, ,BACTEC 460, E-test33/50(2/0)None   
101779 Secondary Publication: O'Sullivan DM JAntiChemo 2005 TCG/TGG 522Ser/Trp           High confidence details 
101880 El Baghdadi J IJTLD 2003 CCC/ACC 523Gly/Trp1996-2001MoroccoSequencingRRDRRHSN.S.Resistance ratio method101/122(1/0)    
101981 Pozzi G JCM 1999 GGG/TGG 523Gly/TrpPublished April 2000ItalySequencingRRDRRH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/mlAbsolute concentration method37/37(1/0)Triple mutation with GAC516TAC and ACC525ATC   
102082 Bahrmand AR JCM 2009 GGG/GCG 523Gly/Ala2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/28625/0rpoB T508A or S531L or L511V, or H526R   
102183 Valim A JCM 2000 TTG/TGG 524Leu/Trp1996-1998BrazilSequencingRRDRMDRN.S.Proportion method82/100(1/0)Same isolate had changes in codons 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)   
102284 Zenteno-Cuevas R MemInstOswaldCruz 2009 TTG/TCG 524Leu/Ser2007MexicoSequencingRRDRHRN.S.BACTEC 46015/251/0rpoB S531L   
102385 Valim A JCM 2000 ACC/CCC 525Thr/Pro1996-1998BrazilSequencingRRDRMDRN.S.Proportion method82/100(1/0)Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)   
102486 Pozzi G JCM 1999 ACC/ATC 525Thr/IlePublished April 2001ItalySequencingRRDRRH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/mlProportion method37/37(1/0)Triple mutation with GAC516TAC and GGG523TGG   
102587 Bahrmand AR JCM 2009 CAC/TTC 526His/Phe2005-2006IranSequencing411bp fragment of rpoB41R, 37MDR>100 ug/mlProportion method41/2862/0rpoB S512T, G513N, S531L   
102688 Ramaswamy SV J Med Micro 2004 CAC/AAC 526His/Asn1996-2001MexicoSequencing RHSEN.S.Proportion method37/50(1/0)rpoB: Double mutation with 435 GAC/GAG; embB: 306 ATG/ATA1 High confidence details 
102789 Kapur V JCM 1994 CAC/GAC 526His/AspPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1288/0None described in the region sequenced. High confidence details 
102890 Kapur V JCM 1994 CAC/TAC 526His/TyrPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/12839/0None described in the region sequenced. High confidence details 
102991 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/ACC 526His/Thr             
103092 Prammananan T CMI 2008 CAC/AGC 526His/Ser2003-2005ThailandSequencingWhole geneMDRN.S.Proportion method154/1131/0rpoB 515 ATG/CTG   
103193 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/GGC 526His/Gly             
103294 Kim BJ JCM 1997 CAC/TGC 526His/CysPublished 1997South KoreaPCR-SSCP, SequencingRRDRRN.S.Absolute concentration method. 32/582/0Location of double mutants not specified.   
103395 Kim BJ JCM 1997 CAC/CGC 526His/ArgPublished 1997South KoreaPCR-SSCP, SequencingRRDRRN.S.Absolute concentration method. 32/581/0Location of double mutants not specified. High confidence details 
103496 Bodmer T JAC 1995 CAC/CCC 526His/ProPublished 2001N.S.PCR-SSCPRRDRR8ug/mlBACTEC 46026/36(2/0)    
103597 Valim A JCM 2000 CAC/CTG 526His/Leu1996-1998BrazilSequencingRRDRRHSEZEthN.S.Proportion method82/100(1/0)Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 527 del AAG(Lys)   
103698 Sheng J JApplMicro 2008 CAC/CTT 526His/Leu2002-2003ChinaPCR-SSCP , SequencingRRDRRN.S.Agar proportion method 49/561/0None in rpoB   
103799 Kapur V JCM 1994 CAC/CTC 526His/LeuPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1282/0None described in the region sequenced. High confidence details 
1038100 Kapur V JCM 1994 CAC/CAA 526His/GlnPublished 1994USASequencingWhole geneRN.S.Proportion method, BACTEC121/1281/0Also mutated at Ser456Cys.   
1039101 Bodmer T JAC 1995 CAC/CAG 526His/GlnPublished 2003N.S.PCR-SSCPRRDRR>8ug/mlBACTEC 46026/36(2/0)Double mutation with 498 Val/Ala   
1040102 Siddiqi N AAC 2002 AAG/AAT 527Lys/Asn1995-1998IndiaSequencingRRDRHRH40 ug/mlProportion method94/126(2/0)1) katG or inhA R463L; 2) katG or inhA R463L, rpoB dual mutation with L521L   
1041103 Valim A JCM 2000 del AAG 527del Lys1996-1998BrazilSequencingRRDRRHSEZEthN.S.Proportion method82/100(1/0)Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu)   
1042104 Williams D AAC 1994 AAG/CAG 527Lys/GlnPublished 1995USAPCR-HDF, SequencingRRDRRHEEtN.S.Proportion method108/120(1/0)Double mutation with 526 (His)   
1043105 Siddiqi N AAC 2002 CGC/CAC 528Arg/His1995-1998IndiaSequencingRRDRHR, ROS64-128 ug/mlProportion method94/126(2/0)1) rpoB dual mutation with H526Y; gyrA S95T; rpsL NM; 2) rpoB 1 dual mutation with with S531W; katG and inhA R463L, Inh (C/T)   
1044106 Siddiqi N AAC 2002 CGC/CCC 528Arg/Pro1995-1998IndiaSequencingRRDRROS, RHO, RHS, RH40-64 ug/ml*Proportion method94/126(4/0)1) rpoB dual mutation with N518T; gyrA S95T; rpsL NM; 2) katG or inhA NA; gyrA S95T; 3) katG or inhA R463L; rpsL K121K; 4) katG or inhA R463L; rpoB dual mutation with H526Y   
1045107 Zenteno-Cuevas R MemInstOswaldCruz 2009 CGC/CCT 528Arg/Pro2007MexicoSequencingRRDRHRSEZN.S.BACTEC 46015/251/0None   
1047109 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/CAG 531Ser/Gln             
1048110 Donabella V Am J Respir Cell Mol Biol 1994 TCG/TTG 531Ser/LeuPublished 1994USASequencingRRDRRN.S. (1/9)(1/0)  High confidence details 
1049111 Bodmer T JAC 1995 TCG/TGG 531Ser/TrpPublished 2005N.S.PCR-SSCPRRDRR8ug/mlBACTEC 46026/36(1/0)  High confidence details 
1050112 Bodmer T JAC 1995 TCG/TAT 531Ser/TyrPublished 2006N.S.PCR-SSCPRRDRR>8ug/mlBACTEC 46026/36(1/0)    
1051113 Hillemann D AAC 2005 TCG/TTT 531Ser/Phe2001Germanyreal-time sequencingRRDRMDRN.S. 103/113(2/0)katG 315 AGC-ACC/Ser-Thr   
1052114 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/TGT 531Ser/Cys             
1053115 Moghazeh SL AAC 1996 CTG/CCG 533Leu/Pro1992-1995USASequencingN.SR>32ug/mlProportion method24/241/0None described in the region sequenced. High confidence details 
1054116 Valim A JCM 2000 CTG/CCT 533Leu/Pro1996-1998BrazilSequencingRRDRRH, RHSN.S.Proportion method82/100(2/0)Same isolate had double mutation: 526 CAC(His)/CTG(Leu)   
1055117 Tracevska T JCM 2002 CCC/TCC 535Pro/Ser1999-2000LatviaLine probe assay, SequencingRRDRR, RHN.S.Absolute concentration method, BACTEC 51/70(4/0)Double mutation with D516Y   
1056118 Prammananan T CMI 2008 CCC/CAC 535Pro/His2003-2005ThailandSequencingWhole geneMDRN.S.Proportion method154/1131/0rpoB 526 CAC/AGC His/Ser   
1046108 Wang Q JProtRes 2007 TCG/TAG 538Leu/STOPPublished 1997ChinaSequencingWhole geneRN.S.Proportion method, absolute concentration method112/301/0    
1057119 Wang Q JProtRes 2007 CTG/CCG 538Leu/ProPublished 1997ChinaSequencingWhole geneRN.S.Proportion method, absolute concentration method112/301/0  High confidence details 
1058120 Prammananan T CMI 2008 GAG/GGG 541Glu/Gly2003-2005ThailandSequencingWhole geneMDRN.S.Proportion method154/1131/0rpoB 526 CAC/TAC His/Tyr   
1059121 Pozzi G JCM 1999 GAG/GAT 541Glu/GlyPublished 2002ItalySequencingRRDRRH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/mlProportion method37/37(1/0)Triple mutation with CAC526GAC and TCG553GCG   
1060122 Aslan G JpnJInfectDis 2008 CTG/ATG 545Leu/Met2003-2006TurkeySequencingRRDRR or MDRN.S.BACTEC 46019/413/0rpoB S531A, katG S315T   
1061123 Pozzi G JCM 1999 TCG/GCG 553Ser/AlaPublished 2003ItalySequencingRRDRRH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/mlProportion method37/37(1/0)Triple mutation with CAC526GAC and GAG541GAT   
1062124 Ramaswamy SV J Med Micro 2004 ATC/GTC 561Ile/Val1996-1998MexicoSequencingRRDRRHSEN.S.Proportion method37/50(1/0)rpoB: Double mutation with 450 TCG/TTG; embB: 306 ATG/ATA   
1063125 Heep M JCM 2001 ATC/ACC 561Ile/Thr1997GermanySequencingRRDRN.S.N.S.Proportion method111/111(1/0)Double mutation with S456L   
1064126 Hauck Y JAC 2009 GAA/GGA 562Glu/GlyPublished 2009VariousSequencingRRDRR<1 ug/mlMGIT 960122/1221/0rpoB P564L   
1065127 Hauck Y JAC 2009 CCT/CTT 564Pro/LeuPublished 2009VariousSequencingRRDRR<1 ug/mlMGIT 960122/1221/0rpoB E562G   
1066128 Heep M JCM 2001 CTG/GTG 571Leu/Val1997GermanySequencingRRDRRHEZN.S.Proportion method111/111(2/0)Double mutation with D441Y   
1067129 Yuen LK JCM 1999 ATC/TTC 572Ile/Phe1990-1997VietnamSequencingRRDRRHE> 256 ug/mlResistance ratio method, BACTEC 460, E-test33/50(1/0)None   
1068130 Chan RCY JAC 2007 TCG/TTG 574Ser/Leu1994-2004Hong KongPCR-SSCP, SequencingRRDRRHEZ>64 ug/mlAbsolute concentration method. 221/2501katG 311 Asp/Gly High confidence details 
1069131 Prammananan T CMI 2008 TCG/GCG 622Ser/Ala2003-2005ThailandSequencingWhole geneMDRN.S.Proportion method154/1131/0rpoB 531 TCG/TTG ser/Leu   
1070132 Heep M JCM 2001 CGC/TGC 633Arg/Cys1997GermanySequencingRRDRRHN.S.Proportion method, BACTEC 460111/111(1/0)Double mutation with S456L   
1071133 Heep M JCM 2001 GAG/GAT 672Glu/Asp1997GermanySequencingRRDRRH, RHE, RHZ, RHEZN.S.Proportion method, BACTEC 460111/111(7/0)Double mutation with S456W   

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