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PYRAZINAMIDE [PZA]


pncA: Rv2043c

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Codons 280 to 299:1 Mutation Codons 240 to 259:1 Mutation Codons 180 to 199:5 Mutation Codons 160 to 179:17 Mutation Codons 140 to 159:29 Mutation Codons 120 to 139:45 Mutation Codons 100 to 119:23 Mutation Codons 80 to 99:24 Mutation Codons 60 to 79:34 Mutation Codons 40 to 59:39 Mutation Codons 20 to 39:18 Mutation Codons 0 to 19:42 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
5473 Sreevatsan S AAC 1997 A/G-11-11 1996Diverse geographical locationsSequencingWhole geneZ BACTEC 460 67/1182/0  High confidence details 
740196 Sreevatsan S AAC 1997 ins AGGTCGATG388 Ins Arg Ser Met1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1184/0  High confidence details 
5539 Lemaitre N AAC 1999 GCG/CCG73Ala/Pro1986FranceSequencingWhole geneZHR1000  1/0  High confidence details 
55410 Sekiguchi JI JCM 2007 GCG/GAG83Ala/Glu2006JapanMulti-plex PCRWhole geneZ Proportion method, rapid broth method17/1381/0  High confidence details 
56016 Hirano K TLD 1997 GTC/GGC207Val/Gly1997YemenSequencingWhole geneZHRSE>800Proportion method33/1682/0  High confidence details 
56319 Lee KW J Korean Med Sci 2001 GAC/GGC238Asp/Gly2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
56521 Lee KW J Korean Med Sci 2001 GTG/GCG269Val/Ala2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
56622 Lee KW J Korean Med Sci 2001 GTG/GGG269Val/Gly2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
57329 Hirano K TLD 1997 CAG/CCG2910Gln/Pro1997MyanmarSequencingWhole geneZHRSE>800Proportion method33/1681/0  High confidence details 
57632 Scorpio A AAC 1997 GAC/GCC3512Asp/Ala1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/461/0  High confidence details 
57834 Scorpio A AAC 1997 TGC/CGC4014Cys/Arg1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/461/0  High confidence details 
57935 Louw GE Int J Tuberc Lung Dis 2006 TGC/CGC4014Cys/His2001-2002South AfricaSequencingWhole geneZHRSEthK BACTEC MGIT 96011568  High confidence details 
58238 Hirano K TLD 1997 GGC/GAC5017Gly/Asp1997ThailandSequencingWhole geneZHRS>800Proportion method33/1682/0  High confidence details 
58541 Chan RCY JAC 2007 CTG/CGG5619Leu/Arg1994-2004Hong KongPCR-SSCP , SequencingWhole geneZ BACTEC MGIT 96025089  High confidence details 
58642 Sreevatsan S AAC 1997 CTG/CCG5619Leu/Pro1996Diverse geographical locationsSequencingWhole geneZ BACTEC 460 67/1181/0  High confidence details 
58743 Chan RCY JAC 2007 GTA/GGA6221Val/Gly1994-2004Hong KongPCR-SSCP , SequencingWhole geneZ BACTEC MGIT 96025089  High confidence details 
60056 Hirano K TLD 1997 TAC/TCC10134Tyr/Ser1997ThailandSequencingWhole geneZHRSE>800Proportion method33/1682/0  High confidence details 
60157 Stavrum R PlosOne 2009 CTG/CCG10435Leu/ProPublished 2009IndiaSequencingWhole gene  N.S. 1/0  High confidence details 
60258 Louw GE Int J Tuberc Lung Dis 2006 CTG/CGG10435Leu/Arg2001-2002South AfricaSequencingWhole geneZHRSEthK BACTEC MGIT 96011568  High confidence details 
60763 Sreevatsan S AAC 1997 TAC/TAG12341Tyr/STOP1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
60864 Hirano K TLD 1997 CAC/CCC12843His/Pro1997ThailandSequencingWhole geneZHR>800Proportion method33/1681/0  High confidence details 
60965 Lee KW J Korean Med Sci 2001 GTG/GGG13445Val/Gly2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
61369 Cheng SJ AAC 2000 GCA/GTA13746Ala/Val South koreaSequencingWhole geneZ>500Proportion method, BACTEC 46059/591/0  High confidence details 
61672 Sreevatsan S AAC 1997 ACC/GCC13947Thr/Ala1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/11811/0  High confidence details 
61874 Lee KW J Korean Med Sci 2001 GAC/GCC14649Asp/Ala2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
62076 Marttila HJ AAC 1999 GAC/GGC14649Asp/Gly1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/441/0not tested High confidence details 
62278 Mestdagh M AAC 1999 CAC/TAC15151His/Tyr1999ScotlandSequencingWhole geneZ BACTEC 460 23/621/0  High confidence details 
62480 Hirano K TLD 1997 CAC/CCC15251His/Pro1997ThailandSequencingWhole geneZHR>800Proportion method33/1681/0  High confidence details 
62581 Hirano K TLD 1997 CAC/CGC15251His/Arg1997ThailandSequencingWhole geneZHR>800Proportion method33/1681/0  High confidence details 
62985 Cheng SJ AAC 2000 GAC/GCC15853Asp/Ala South koreaSequencingWhole geneZ>100Proportion method, BACTEC 46059/591/0  High confidence details 
63187 Sreevatsan S AAC 1997 CCG/ACG16054Pro/Thr1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
63692 Louw GE Int J Tuberc Lung Dis 2006 CAC/TAC16957His/Tyr2001-2002South AfricaSequencingWhole geneZHRSEthK BACTEC MGIT 96011568  High confidence details 
63894 Brown TJ JMedMicro 2000 CAC/CCC17057His/Pro2000TurkeySequencingWhole geneZHRP BACTEC radiometric-based culture method, standard protocol; and PZase activity13/181/0A2416T (rpoB) High confidence details 
644100 Lemaitre N AAC 1999 ACA/CCA18161Thr/Pro1992FranceSequencingWhole geneZHRES500ug/ml 19/351/0  High confidence details 
648104 Hirano K TLD 1997 GAC/GGC18863Asp/Gly1997YemenSequencingWhole geneZHRS>800Proportion method33/1681/0  High confidence details 
653109 Marttila HJ AAC 1999 TCG/CCG19666Ser/Pro1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/441/0not tested High confidence details 
654110 Hirano K TLD 1997 TCG/CCG19967Ser/Pro1997CanadaSequencingWhole geneZHRSE>800Proportion method33/1681/0  High confidence details 
655111 Lee KW J Korean Med Sci 2001 TGG/CGG20268Trp/Arg2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
656112 Lee KW J Korean Med Sci 2001 TGG/GGG20268Trp/Gly2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
659115 Sreevatsan S AAC 1997 TGG/TTG20368Trp/Leu1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
665121 Morlock GP AAC 2000 CAT/CGT21271His/Arg1999 SequencingWhole geneZ>800Proportion method37/601/0  High confidence details 
667123 Scorpio A AAC 1997 TGC/CGC21472Cys/Arg1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/461/0  High confidence details 
674130 Sreevatsan S AAC 1997 ACT/CCT22676Thr/Pro1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
676132 Morlock GP AAC 2000 GGC/GAC23378Gly/Asp1999 SequencingWhole geneZ>800Proportion method37/601/0  High confidence details 
681137 Cheng SJ AAC 2000 CAT/CGT24582His/Arg USASequencingWhole geneZHRES300Proportion method, BACTEC 46059/591/0  High confidence details 
684140 Mestdagh M AAC 1999 CTG/CGG25485Leu/Arg1999AzerbaijanSequencingWhole geneZ BACTEC 460 23/621/0  High confidence details 
685141 Scorpio A AAC 1997 CTG/CCG25485Leu/Pro1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/463/0  High confidence details 
698154 Scorpio A AAC 1997 AAG/AAT28896Lys/Asn1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/461/0  High confidence details 
700156 Cheng SJ AAC 2000 GGT/AGT28997Gly/Ser USASequencingWhole geneZHRES>900Proportion method, BACTEC 46059/592/0  High confidence details 
701157 Morlock GP AAC 2000 GGT/GAT29097Gly/Asp1999 SequencingWhole geneZ400Proportion method37/601/0  High confidence details 
703159 Morlock GP AAC 2000 TAC/TAG29799Tyr/STOP1999 SequencingWhole geneZ>800Proportion method37/602/0  High confidence details 
707163 Marttila HJ AAC 1999 GCG/GTG305102Ala/Val1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/442/0not tested High confidence details 
711167 Lee KW J Korean Med Sci 2001 TAC/TCC308103Tyr/Ser2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/952/0  High confidence details 
713169 Marttila HJ AAC 1999 TAC/TAG309103Tyr/STOP1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/441/0not tested High confidence details 
716172 Hirano K TLD 1997 AGC/AGG312104Ser/Arg1997YemenSequencingWhole geneZHRSE>800Middlebrook 7H11 agar w/ pH of 6.033/1681/0  High confidence details 
718174 Hirano K TLD 1997 ACG/CCG340114Thr/Pro1997YemenSequencingWhole geneZHR>800Middlebrook 7H11 agar w/ pH of 6.033/1681/0  High confidence details 
722178 Marttila HJ AAC 1999 CTG/CGG347116Leu/Arg1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/441/0not tested High confidence details 
724180 Sreevatsan S AAC 1997 TGG/CGG355119Trp/Arg1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
727183 Portugal I AAC 2004 CTG/CCG359120Leu/Pro2000-2001PortugalSequencingWhole geneZ BACTEC MGIT 9605555  High confidence details 
728184 Sreevatsan S AAC 1997 CGG/CCG362121Arg/Pro1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
732188 Peridgao J MDR 2008 GTC/GGC374125Val/Gly2003PortugalSequencingWhole geneZHRS MGIT 96048/5819/0  High confidence details 
737193 Rodrigues V de F AAC 2005 GTC/GGC384128Val/Gly1998-2003BrazilSequencingWhole geneZ Proportion method and Pzase test5940  High confidence details 
741197 Hirano K TLD 1997 GTG/GGG389130Val/Gly1997CanadaSequencingWhole geneZHRSE>800Middlebrook 7H11 agar w/ pH of 6.033/1681/0  High confidence details 
746202 Hirano K TLD 1997 GGT/GAT395132Gly/Asp1997MyanmarSequencingWhole geneZ>800Proportion method33/1681/0  High confidence details 
747203 Scorpio A AAC 1997 GGT/AGT394132Gly/Ser1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/462/0  High confidence details 
752208 Escalante P TuberLung Dis 1998 GCC/GTC401134Ala/Val1995-1996PeruSequencingWhole geneZHRP Proportion method401461/0katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; High confidence details 
763219 Sreevatsan S AAC 1997 CAT/CGT410137His/Arg1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1182/0  High confidence details 
765221 Scorpio A Nature Med 1996 TGT/TAT413138Cys/Tyr USA (Colorado)SequencingWhole geneMDR>500ug/mlPzase testing by Wayne's method399101/0  High confidence details 
767223 Cheng SJ AAC 2000 GTG/ATG415139Val/Met South koreaSequencingWhole geneZ>500Proportion method, BACTEC 46059/591/0?  High confidence details 
768224 Morlock GP AAC 2000 GTG/CTG415139Val/Leu1999 SequencingWhole geneZ100Proportion method37/601/0  High confidence details 
769225 Morlock GP AAC 2000 GTG/GGG416139Val/Gly1999 SequencingWhole geneZ>800Proportion method37/601/0  High confidence details 
770226 Sreevatsan S AAC 1997 GTG/GCG416139Val/Ala1996Diverse geographical locationsSequencingWhole geneZ BACTEC 46067/1181/0  High confidence details 
772228 Cheng SJ AAC 2000 CGC/AGC418140Arg/Ser  SequencingWhole geneZ Proportion method, BACTEC 46059/5920/0  High confidence details 
777233 Scorpio A Nature Med 1996 CAG/CCG422141Gln/Pro USASequencingWhole geneMDR>500ug/mlPzase testing by Wayne's methodinvitro1/0  High confidence details 
778234 Escalante P TuberLung Dis 1998 ACG/CCG424142Thr/Pro1995, 1996PeruSequencingWhole geneMDR Proportion method401461/0rpoB, 516, GAC/TAC High confidence details 
780236 Scorpio A AAC 1997 ACG/AAG425142Thr/Lys1992-1995 PCR-SSCPWhole geneZ>900ug/mlPzase testing by Wayne's method46/461/0  High confidence details 
785241 Hirano K TLD 1997 GCG/GTG437146Ala/Val1997IndiaSequencingWhole geneZRS>800Proportion method33/1681/0  High confidence details 
787243 Sekiguchi JI JCM 2007 CGC/AGC442148Arg/Ser2006PolandMulti-plex PCRWhole geneZ Proportion method, rapid broth method17/1381/0  High confidence details 
795251 Lemaitre N AAC 1999 GTG/GGG464155Val/Gly1987FranceSequencingWhole geneZHRE1500 19/351/0  High confidence details 
796252 Escalante P TuberLung Dis 1998 GTG/GCG464155Val/Ala1995, 1996PeruSequencingWhole geneZHRES Proportion method401461/0katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; High confidence details 
799255 Louw GE Int J Tuberc Lung Dis 2006 CTG/CCG476159Leu/Pro2001-2002South AfricaSequencingWhole geneZHRSEthK BACTEC MGIT 96011568  High confidence details 
800256 Lee KW J Korean Med Sci 2001 CTG/CGG476159Leu/Arg2001South koreaSequencingWhole geneZ PZase test with Wayne's method92/951/0  High confidence details 
801257 Marttila HJ AAC 1999 ACA/CCA478160Thr/Pro1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/442/0not tested High confidence details 
803259 Marttila HJ AAC 1999 GCG/CCG481161Ala/Pro1994-1997RussiaSequencingWhole geneZ BACTEC 460 36/442/0not tested High confidence details 
804260 Chan RCY JAC 2007 GGT/GAT485162Gly/Asp1994-2004Hong KongPCR-SSCP , SequencingWhole geneZOREth100mg/LBACTEC MGIT 96089/2501/0Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB) High confidence details 
808264 Sachais BS MolDiag 1998 GCG/CCG511171Ala/Pro1993-1999USASequencingWhole geneZ BACTEC at pH 6.4398561/0  High confidence details 
809265 Mestdagh M AAC 1999 GCG/GTG512171Ala/Val1999ScotlandSequencingWhole geneZ BACTEC 460 23/621/0  High confidence details 
810266 Rodrigues V de F AAC 2005 GCG/GAG512171Ala/Glu1998-2003BrazilSequencingWhole geneZ Proportion method5940  High confidence details 
812268 Hirano K TLD 1997 CTG/CCG515172Leu/Pro1997CanadaSequencingWhole geneZHRSE>800Proportion method33/1681/0  High confidence details 
821277 Louw GE Int J Tuberc Lung Dis 2006 AGC/ACC554185Ser/Thr2001-2002South AfricaSequencingWhole geneZHRSEthK BACTEC MGIT 96011568  High confidence details 

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