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PYRAZINAMIDE [PZA]

Rv2043c

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ID	SeqNo	Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations
545	1	Marttila HJ AAC 1999	T/G	-12	-12		1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
546	2	Scorpio A AAC 1997	A/C	-11	-11		1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
547	3	Sreevatsan S AAC 1997	A/G	-11	-11		1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	2/0
548	4	Morlock GP AAC 2000	T/C	-7	-7		1999		Sequencing	Whole gene	Z	100	Proportion method	37/60	1/0
597	53	Hannan MM JCM 2001	del 24bp	88-112		Frameshift	1996-1999	California, USA	Sequencing	Whole gene	Z		BACTEC radiometric testing	39883	1/0
598	54	Scorpio A AAC 1997	del 118bp	98-216		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
604	60	Morlock GP AAC 2000	del 5.3kb	106		Frameshift/Truncation	1999		Sequencing	Whole gene	Z	800	Proportion method	37/60	1/0
623	79	Lee KW J Korean Med Sci 2001	del 80bp	151-230		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
652	108	Mestdagh M AAC 1999	del 68bp	195-263		Frameshift	1999	Azerbaijan	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
670	126	Lemaitre N AAC 1999	ins 29bp	215		Frameshift	1986	France	Sequencing	Whole gene	ZHRS	>2000		19/35	1/0
671	127	Sekiguchi JI JCM 2007	ins CGCATTGCCG	218		Frameshift	2006		Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
678	134	Brown TJ JMedMicro 2000	del A	239		Frameshift	2000	Turkey	Sequencing	Whole gene	Z		BACTEC 460	13/18	1/0	C2431T (rpoB)
683	139	Peridgao J MDR 2008	ins C	250		Frameshift	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	3/0
691	147	Peridgao J MDR 2008	ins T	282		Frameshift	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	1/0
696	152	Hirano K TLD 1997	ins T	287		Frameshift	1997	Canada	Sequencing	Whole gene	ZHRS	>800	Proportion method	33/168	1/0
697	153	Lee KW J Korean Med Sci 2001	ins T	287		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
699	155	Scorpio A Nature Med 1996	del G	288		Frameshift		USA	Sequencing	Whole gene	Z	>500ug/ml	PZase test with Wayne's method	39910	1/0
704	160	Cheng SJ AAC 2000	ins G	301		Frameshift		South korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0
705	161	Hou L Epi Infect 2000	ins A	301		Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZHRS	900	Proportion method, BACTEC 460	35/65	1/0
708	164	Lemaitre N AAC 1999	ins C	306		Frameshift	1989	France	Sequencing	Whole gene	ZHRES	500-1500		19/35	1/0
710	166	Lee KW J Korean Med Sci 2001	del TACAG	307		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
719	175	Cheng SJ AAC 2000	del C	341		Frameshift		South Korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0?
720	176	Lemaitre N AAC 1999	ins 1355bp	341		Frameshift	1989	France	Sequencing	Whole gene	ZHRE	1000		19/35	1/0
729	185	Hou L Epi Infect 2000	ins AG	368		Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZRHSE	1000	Proportion method, BACTEC 460	35/65	1/0
730	186	Lee KW J Korean Med Sci 2001	ins 18bp	368		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
733	189	Marttila HJ AAC 1999	del 11bp	379-389		Frameshift	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
734	190	Lee KW J Korean Med Sci 2001	del GG	381		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
735	191	Peridgao J MDR 2008	del 9bp	381		Frameshift	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	1/0
736	192	Lee KW J Korean Med Sci 2001	ins AG	382		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
738	194	Lee KW J Korean Med Sci 2001	del ATGT	386-389		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
739	195	Morlock GP AAC 2000	ins GAGGTCGAT	388		ins Glu Val Asp	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
740	196	Sreevatsan S AAC 1997	ins AGGTCGATG	388		Ins Arg Ser Met	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	4/0
742	198	Lee KW J Korean Med Sci 2001	ins GG	391		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
743	199	Lemaitre N AAC 1999	ins GG	391		Frameshift	1988	France	Sequencing	Whole gene	ZHRES	500-1000		19/35	1/0
744	200	Scorpio A AAC 1997	del G	391		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
745	201	Lee KW J Korean Med Sci 2001	ins G	392		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
748	204	Hirano K TLD 1997	del 16bp	395-411 del		Frameshift	1997	India	Sequencing	Whole gene	ZR	>800	Proportion method	33/168	1/0
749	205	Sreevatsan S AAC 1997	ins T	397		Frameshift	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
754	210	Hou L Epi Infect 2000	ins CC	403		Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZRE	1000	Proportion method, BACTEC 460	35/65	1/0
755	211	Sreevatsan S AAC 1997	ins C	403		Frameshift	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
759	215	Lee KW J Korean Med Sci 2001	del G	406		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
761	217	Mestdagh M AAC 1999	ins C	407-408		Frameshift	1999	Azerbaijan	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
766	222	Lee KW J Korean Med Sci 2001	ins G	414		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
771	227	Scorpio A AAC 1997	del TG	416		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
773	229	Lemaitre N AAC 1999	del 68bp	419		Frameshift	1992	France	Sequencing	Whole gene	ZHRE	1000		19/35	1/0
774	230	Cheng SJ AAC 2000	ins G	420		Frameshift		USA	Sequencing	Whole gene	ZR	>900	Proportion method, BACTEC 460	59/59	1/0
775	231	Cheng SJ AAC 2000	ins GG	420		Frameshift		USA	Sequencing	Whole gene	ZHRSO	>900	Proportion method, BACTEC 460	59/59	1/0
782	238	Cheng SJ AAC 2000	ins GG	428		Frameshift		South korea	Sequencing	Whole gene	Z	>100	Proportion method, BACTEC 460	59/59	1/0?
784	240	Lemaitre N AAC 1999	del G	436		Frameshift	1987	France	Sequencing	Whole gene	ZHRE	1000-1500		19/35	1/0
786	242	Peridgao J MDR 2008	ins CG	439		Frameshift	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	1/0
789	245	Scorpio A AAC 1997	del G	443		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
790	246	Cheng SJ AAC 2000	del 8bp	446		Frameshift	1990-1992	Canada	Sequencing	Whole gene	ZHRE	>300	Proportion method, BACTEC 460	59/59	1/0
791	247	Scorpio A AAC 1997	ins 8bp	446		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
792	248	Lee KW J Korean Med Sci 2001	del T	452		Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
797	253	Lee KW J Korean Med Sci 2001	ins T	465		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	2/0
798	254	Scorpio A AAC 1997	del C	475		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
802	258	Lee KW J Korean Med Sci 2001	ins TGAC	480		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
805	261	Hou L Epi Infect 2000	ins CG	501		Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZSHE	900	Proportion method, BACTEC 460	35/65	1/0
811	267	Mestdagh M AAC 1999	del C	512		Frameshift	1999	Rwanda	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
814	270	Scorpio A AAC 1997	ins 5bp	518		Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
816	272	Lee KW J Korean Med Sci 2001	ins C	532		Frameshift	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
549	5	Hou L Epi Infect 2000	del 8bp	1	1	Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZRHSE	>2000	Proportion method, BACTEC 460	35/65	1/0
550	6	Scorpio A AAC 1997	del 11bp	1	1	Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	2/0
551	7	Portugal I AAC 2004	ATG/ACG	2	1	Met/Thr	2000-2001	Portugal	Sequencing	Whole gene	Z		BACTEC MGIT 960	55	55
552	8	Lee KW J Korean Med Sci 2001	ATG/ATT	3	1	Met/Ile	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
553	9	Lemaitre N AAC 1999	GCG/CCG	7	3	Ala/Pro	1986	France	Sequencing	Whole gene	ZHR	1000			1/0
554	10	Sekiguchi JI JCM 2007	GCG/GAG	8	3	Ala/Glu	2006	Japan	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
555	11	Lee KW J Korean Med Sci 2001	TTG/TGG	11	4	Leu/Trp	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
556	12	Morlock GP AAC 2000	TTG/TCG	11	4	Leu/Ser	1999		Sequencing	Whole gene	Z	800	Proportion method	37/60	1/0
557	13	Scorpio A AAC 1997	ATC/AGC	14	5	Ile/Ser	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
558	14	Escalante P TuberLung Dis 1998	GTC/ATC	19	7	Val/Ile	1995, 1996	Peru	Sequencing	Whole gene	ZHRPES		Proportion method	40146	1/0	katG, 315, AGC/ACC; rpoB, 531, TCG/TTG;
559	15	Escalante P TuberLung Dis 1998	GTC/TTC	19	7	Val/Phe	1995, 1996	Peru	Sequencing	Whole gene	ZHRPS		Proportion method	40146	1/0	katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; embB, 328, GAT:A del
560	16	Hirano K TLD 1997	GTC/GGC	20	7	Val/Gly	1997	Yemen	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	2/0
561	17	Lee KW J Korean Med Sci 2001	GTC/GAC	20	7	Val/Asp	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
562	18	Marttila HJ AAC 1999	GAC/TAC	22	8	Asp/Tyr	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
563	19	Lee KW J Korean Med Sci 2001	GAC/GGC	23	8	Asp/Gly	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
564	20	Scorpio A AAC 1997	GAC/GAG	24	8	Asp/Glu	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
565	21	Lee KW J Korean Med Sci 2001	GTG/GCG	26	9	Val/Ala	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
566	22	Lee KW J Korean Med Sci 2001	GTG/GGG	26	9	Val/Gly	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
567	23	Louw GE Int J Tuberc Lung Dis 2006	GTG/TTG	26	9	Val/Leu	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
568	24	Chan RCY JAC 2007	GTG/TCG	27	9	Val/Ser	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
569	25	Scorpio A AAC 1997	del C	28	10	Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
570	26	Marttila HJ AAC 1999	CAA/AAA	28	10	Gln/Lys	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
571	27	Marttila HJ AAC 1999	CAA/TAA	28	10	Gln/STOP	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
572	28	Cheng SJ AAC 2000	CAG/CGA	29	10	Gln/Arg	1990-1992	USA	Sequencing	Whole gene	ZHREO	>900	Proportion method, BACTEC 460	59/59	1/0
573	29	Hirano K TLD 1997	CAG/CCG	29	10	Gln/Pro	1997	Myanmar	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	1/0
574	30	Morlock GP AAC 2000	CAG/CCA	29	10	Gln/Pro	1999		Sequencing	Whole gene	Z	800	Proportion method	37/60	1/0
575	31	Scorpio A AAC 1997	GAC/AAC	34	12	Asp/Asn	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
576	32	Scorpio A AAC 1997	GAC/GCC	35	12	Asp/Ala	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
577	33	Lemaitre N AAC 1999	TTC/TCC	38	13	Phe/Ser	1987	France	Sequencing	Whole gene	ZHRES	>2000		19/35	1/0
578	34	Scorpio A AAC 1997	TGC/CGC	40	14	Cys/Arg	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
579	35	Louw GE Int J Tuberc Lung Dis 2006	TGC/CGC	40	14	Cys/His	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
580	36	Lee KW J Korean Med Sci 2001	TGC/TAC	41	14	Cys/Tyr	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
581	37	Chan RCY JAC 2007	del G	47	16	Frameshift	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
582	38	Hirano K TLD 1997	GGC/GAC	50	17	Gly/Asp	1997	Thailand	Sequencing	Whole gene	ZHRS	>800	Proportion method	33/168	2/0
583	39	Chan RCY JAC 2007	GGC/GTC	50	17	Gly/Val	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
584	40	Cheng SJ AAC 2000	ins GG	52	17	Frameshift		USA	Sequencing	Whole gene	ZHR	>900	Proportion method, BACTEC 460	59/59	1/0
585	41	Chan RCY JAC 2007	CTG/CGG	56	19	Leu/Arg	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
586	42	Sreevatsan S AAC 1997	CTG/CCG	56	19	Leu/Pro	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
589	45	Hou L Epi Infect 2000	del C	59	20	Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZRSE	1800	Proportion method, BACTEC 460	35/65	1/0
587	43	Chan RCY JAC 2007	GTA/GGA	62	21	Val/Gly	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
588	44	Chan RCY JAC 2007	del A	64	22	Frameshift	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
590	46	Lee KW J Korean Med Sci 2001	GGT/GTC	68-69	23	Gly/Val	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
591	47	Sreevatsan S AAC 1997	del G	70	24	Frameshift	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	7/0
592	48	Hou L Epi Infect 2000	del G	71	24	Frameshift	1996-1998	China	PCR-SSCP	Whole gene	ZRH	600	Proportion method, BACTEC 460	35/65	1/0
593	49	Lee KW J Korean Med Sci 2001	GCC/GAA	74-75	25	Ala/Glu	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
594	50	Scorpio A AAC 1997	GCG/GGG	77	26	Ala/Gly	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
595	51	Marttila HJ AAC 1999	del C	84	28	Frameshift	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
596	52	Lee KW J Korean Med Sci 2001	GCC/GAC	83	28	Ala/Asp	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
599	55	Scorpio A AAC 1997	ins T	100	34	Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
600	56	Hirano K TLD 1997	TAC/TCC	101	34	Tyr/Ser	1997	Thailand	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	2/0
601	57	Stavrum R PlosOne 2009	CTG/CCG	104	35	Leu/Pro	Published 2009	India	Sequencing	Whole gene			N.S.		1/0
602	58	Louw GE Int J Tuberc Lung Dis 2006	CTG/CGG	104	35	Leu/Arg	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
603	59	Louw GE Int J Tuberc Lung Dis 2006	GGA/TAA	109-110	37	Glu/STOP	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
605	61	Hou L Epi Infect 2000	TAC/CAC	121	41	Tyr/His	1996-1998	China	PCR-SSCP	Whole gene	ZHRE	600	Proportion method, BACTEC 460	35/65	1/0
606	62	Hirano K TLD 1997	TAC/TAA	123	41	Tyr/STOP	1997	Thailand	Sequencing	Whole gene	ZHRSE	>800	Middlebrook 7H11 agar w/ pH of 6.0	33/168	1/0
607	63	Sreevatsan S AAC 1997	TAC/TAG	123	41	Tyr/STOP	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
608	64	Hirano K TLD 1997	CAC/CCC	128	43	His/Pro	1997	Thailand	Sequencing	Whole gene	ZHR	>800	Proportion method	33/168	1/0
609	65	Lee KW J Korean Med Sci 2001	GTG/GGG	134	45	Val/Gly	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
610	66	Hirano K TLD 1997	ins G	136	46	Frameshift	1997	Yemen	Sequencing	Whole gene	ZHE	>800	Proportion method	33/168	1/0
611	67	Louw GE Int J Tuberc Lung Dis 2006	GCA/CCA	136	46	Ala/Pro	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
612	68	Cheng SJ AAC 2000	GCA/GAA	137	46	Ala/Glu		South korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0
613	69	Cheng SJ AAC 2000	GCA/GTA	137	46	Ala/Val		South korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0
614	70	Hou L Epi Infect 2000	ACC/CCC	139	47	Thr/Pro	1996-1998	China	PCR-SSCP	Whole gene	ZRSE	1500	Proportion method, BACTEC 460	35/65	1/0
615	71	Marttila HJ AAC 1999	ACC/TCC	139	47	Thr/Ser	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
616	72	Sreevatsan S AAC 1997	ACC/GCC	139	47	Thr/Ala	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	11/0
617	73	Louw GE Int J Tuberc Lung Dis 2006	GAC/CAC	145	49	Asp/His	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
618	74	Lee KW J Korean Med Sci 2001	GAC/GCC	146	49	Asp/Ala	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
619	75	Marttila HJ AAC 1999	GAC/GTC	146	49	Asp/Val	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
620	76	Marttila HJ AAC 1999	GAC/GGC	146	49	Asp/Gly	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
621	77	Rodrigues V de F AAC 2005	CAC/AAC	151	51	His/Asn	1998-2003	Brazil	Sequencing	Whole gene	Z		Proportion method	59	40
622	78	Mestdagh M AAC 1999	CAC/TAC	151	51	His/Tyr	1999	Scotland	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
624	80	Hirano K TLD 1997	CAC/CCC	152	51	His/Pro	1997	Thailand	Sequencing	Whole gene	ZHR	>800	Proportion method	33/168	1/0
625	81	Hirano K TLD 1997	CAC/CGC	152	51	His/Arg	1997	Thailand	Sequencing	Whole gene	ZHR	>800	Proportion method	33/168	1/0
626	82	Sekiguchi JI JCM 2007	CAC/CAG	153	51	His/Gln	2006	Poland	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
627	83	Sekiguchi JI JCM 2007	CAC/CAA	153	51	His/Gln	2006	Japan	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	2/0
628	84	Sekiguchi JI JCM 2007	GAC/AAC	151	53	Asp/Asn	2006	Japan	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
629	85	Cheng SJ AAC 2000	GAC/GCC	158	53	Asp/Ala		South korea	Sequencing	Whole gene	Z	>100	Proportion method, BACTEC 460	59/59	1/0
630	86	Lee KW J Korean Med Sci 2001	del A	158	53	Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
631	87	Sreevatsan S AAC 1997	CCG/ACG	160	54	Pro/Thr	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
632	88	Louw GE Int J Tuberc Lung Dis 2006	CCG/CTG	161	54	Pro/Leu	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
633	89	Lee KW J Korean Med Sci 2001	del C	161	54	Frameshift	2001	South Korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
634	90	Scorpio A AAC 1997	ins T	162	54	Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
635	91	Scorpio A Nature Med 1996	del G	162	54	Frameshift		USA	Sequencing	Whole gene	MDR	>500ug/ml	7H9 liquid medium, pH5.6; PZase activity assayed according to Wayne's method	39910	1/0
636	92	Louw GE Int J Tuberc Lung Dis 2006	CAC/TAC	169	57	His/Tyr	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
637	93	Sreevatsan S AAC 1997	CAC/GAC	169	57	His/Asp	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	2/0
638	94	Brown TJ JMedMicro 2000	CAC/CCC	170	57	His/Pro	2000	Turkey	Sequencing	Whole gene	ZHRP		BACTEC radiometric-based culture method, standard protocol; and PZase activity	13/18	1/0	A2416T (rpoB)
639	95	Chan RCY JAC 2007	CAC/CTC	170	57	His/Leu	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
640	96	Louw GE Int J Tuberc Lung Dis 2006	del T	172	58	Frameshift	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
641	97	Escalante P TuberLung Dis 1998	TTC/CTC	172	58	Phe/Leu	1995-1996	Peru	Sequencing	Whole gene	ZHR		Proportion method	40146	1/0	katG, 315, AGC/ACC; rpoB, 526 cac/ctc; embB, 306, ATG/ATA
642	98	Hirano K TLD 1997	TTC/TTG	174	58	Phe/Leu	1997	Canada	Sequencing	Whole gene	ZHRS	400	Proportion method	33/168	1/0
643	99	Brown TJ JMedMicro 2000	TCC/CCC	175	59	Ser/Pro	2000	Turkey	Sequencing	Whole gene	ZHRP		BACTEC 460	13/18	1/0	C2431T (rpoB)
644	100	Lemaitre N AAC 1999	ACA/CCA	181	61	Thr/Pro	1992	France	Sequencing	Whole gene	ZHRES	500ug/ml		19/35	1/0
645	101	Mestdagh M AAC 1999	CCG/CAG??	185	62	Pro/His	1999	Azerbaijan	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
646	102	Morlock GP AAC 2000	CCG/CGG	185	62	Pro/Arg	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
647	103	Chan RCY JAC 2007	CCG/CTG	186	62	Pro/Leu	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
648	104	Hirano K TLD 1997	GAC/GGC	188	63	Asp/Gly	1997	Yemen	Sequencing	Whole gene	ZHRS	>800	Proportion method	33/168	1/0
649	105	Scorpio A Nature Med 1996	GAC/CAC	187	63	Asp/His		USA (Colorado)	Sequencing	Whole gene	MDR	>500ug/ml	PZase test with Wayne's method	39910	1/0
650	106	Lee KW J Korean Med Sci 2001	TAT/GAT	190	64	Tyr/Asp	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
651	107	Lemaitre N AAC 1999	ins A	192	64	Frameshift	1996	France	Sequencing	Whole gene	ZSHE	1000ug/ml			1/0
653	109	Marttila HJ AAC 1999	TCG/CCG	196	66	Ser/Pro	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
654	110	Hirano K TLD 1997	TCG/CCG	199	67	Ser/Pro	1997	Canada	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	1/0
655	111	Lee KW J Korean Med Sci 2001	TGG/CGG	202	68	Trp/Arg	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
656	112	Lee KW J Korean Med Sci 2001	TGG/GGG	202	68	Trp/Gly	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
657	113	Cheng SJ AAC 2000	TGG/TCA	203	68	Trp/STOP		USA	Sequencing	Whole gene	Z	>900	Proportion method, BACTEC 460	59/59	1/0
658	114	Lee KW J Korean Med Sci 2001	TGG/TCG	203	68	Trp/Ser	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
659	115	Sreevatsan S AAC 1997	TGG/TTG	203	68	Trp/Leu	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
660	116	Scorpio A AAC 1997	CCA/CGA	206	69	Pro/Arg	1992-1995		PCR-SSCP	Whole gene	Z	>300ug/ml	Pzase testing by Wayne's method	46/46	2/0
661	117	Hou L Epi Infect 2000	CCA/CGA	206	69	Pro/Arg	1996-1998	China	PCR-SSCP	Whole gene	ZRHSE	1200	Proportion method, BACTEC 460	35/65	1/0
662	118	Lemaitre N AAC 1999	CCA/CTA	206	69	Pro/Leu	1994	France	Sequencing	Whole gene	ZHR	(pH 5.6, 5.8) >2000/>2000		19/35	1/0
663	119	Louw GE Int J Tuberc Lung Dis 2006	CAT/TAT	211	71	His/Tyr	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
664	120	Louw GE Int J Tuberc Lung Dis 2006	CAT/GAT	212	71	His/Asp	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
665	121	Morlock GP AAC 2000	CAT/CGT	212	71	His/Arg	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
666	122	Cheng SJ AAC 2000	CAT/CAG	213	71	His/Glu		USA	Sequencing	Whole gene	ZHRS	>900	Proportion method, BACTEC 460	59/59	1/0
667	123	Scorpio A AAC 1997	TGC/CGC	214	72	Cys/Arg	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
668	124	Louw GE Int J Tuberc Lung Dis 2006	TGC/TAC	215	72	Cys/Tyr	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
669	125	Sekiguchi JI JCM 2007	TGC/TGG	216	72	Cys/Trp	2006	Japan	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
672	128	Mestdagh M AAC 1999	ins G	221	74	Frameshift	1999	United Kingdom	Sequencing	Whole gene	Z		BACTEC 460	23/62	2/0
673	129	Chan RCY JAC 2007	ATG/ACG	224	75	Met/Thr	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	ZORH	100ug/ml	BACTEC MGIT 960	89/250	1/0	Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB); Ser315Thr(katG)
674	130	Sreevatsan S AAC 1997	ACT/CCT	226	76	Thr/Pro	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
675	131	Brown TJ JMedMicro 2000	ACT/ATT	227	76	Thr/Ile	2000	United Kindom, Turkey	Sequencing	Whole gene	ZHRP		BACTEC 460	13/18	8/0	C2431T (rpoB)
676	132	Morlock GP AAC 2000	GGC/GAC	233	78	Gly/Asp	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
677	133	Chan RCY JAC 2007	GCG/GGG	236	79	Ala/Gly	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89
679	135	Sachais BS MolDiag 1998	TTC/GTC	241	80	Phe/Val	1993-1999	USA	Sequencing	Whole gene	Z		BACTEC at pH 6.4	39856	1/0
680	136	Brown TJ JMedMicro 2000	CAT/TAT Error? This makes Tyr not Asp.	244	82	His/Asp	2000	Turkey	Sequencing	Whole gene	ZHRP		BACTEC 460	13/18	1/0	A2386T (rpoB)
681	137	Cheng SJ AAC 2000	CAT/CGT	245	82	His/Arg		USA	Sequencing	Whole gene	ZHRES	300	Proportion method, BACTEC 460	59/59	1/0
682	138	Rodrigues V de F AAC 2005	CAT/CTT	246	82	His/Leu	1998-2003	Brazil	Sequencing	Whole gene	Z		Proportion method	59	40
684	140	Mestdagh M AAC 1999	CTG/CGG	254	85	Leu/Arg	1999	Azerbaijan	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
685	141	Scorpio A AAC 1997	CTG/CCG	254	85	Leu/Pro	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	3/0
686	142	Lemaitre N AAC 1999	ACG/ATG	260	87	Thr/Met	1987	France	Sequencing	Whole gene	ZHRES	1000-1500		19/35	1/0
687	143	Hou L Epi Infect 2000	TCG/TAG	263	88	Ser/STOP	1996-1998	China	PCR-SSCP	Whole gene	ZHRES	>2000	Proportion method, BACTEC 460	35/65	1/0
688	144	Hannan MM JCM 2001	ATC/AGC	269	90	Ile/Ser	1996-1999	USA	Sequencing	Whole gene	Z		BACTEC radiometric testing	39883	1/0
689	145	Louw GE Int J Tuberc Lung Dis 2006	ATC/AGC	269	90	Ile/Ser	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
690	146	Sreevatsan S AAC 1997	TTC/CCC	280	94	Phe/Pro	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	2/0	T281C
692	148	Peridgao J MDR 2008	TAC/TAA	285	95	Tyr/STOP	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	1/0
693	149	Lee KW J Korean Med Sci 2001	AAG/CAG	286	96	Lys/Gln	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
694	150	Marttila HJ AAC 1999	AAG/GAG	286	96	Lys/Glu	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
695	151	Scorpio A AAC 1997	AAG/ACG	287	96	Lys/Thr	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
698	154	Scorpio A AAC 1997	AAG/AAT	288	96	Lys/Asn	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
700	156	Cheng SJ AAC 2000	GGT/AGT	289	97	Gly/Ser		USA	Sequencing	Whole gene	ZHRES	>900	Proportion method, BACTEC 460	59/59	2/0
701	157	Morlock GP AAC 2000	GGT/GAT	290	97	Gly/Asp	1999		Sequencing	Whole gene	Z	400	Proportion method	37/60	1/0
702	158	Hirano K TLD 1997	TAC/TAA	297	99	Tyr/STOP	1997	Thailand	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	1/0
703	159	Morlock GP AAC 2000	TAC/TAG	297	99	Tyr/STOP	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	2/0
706	162	Marttila HJ AAC 1999	GCG/ACG	304	102	Ala/Thr	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
707	163	Marttila HJ AAC 1999	GCG/GTG	305	102	Ala/Val	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	2/0	not tested
709	165	Mestdagh M AAC 1999	TAC/CAC	307	103	Tyr/His	1999	Canada	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
711	167	Lee KW J Korean Med Sci 2001	TAC/TCC	308	103	Tyr/Ser	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	2/0
712	168	Lemaitre N AAC 1999	TAC/TGC	308	103	Tyr/Cys	1994	France	Sequencing	Whole gene	ZHRE	1500			1/0
713	169	Marttila HJ AAC 1999	TAC/TAG	309	103	Tyr/STOP	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
714	170	Morlock GP AAC 2000	TAC/TAA	309	103	Tyr/STOP	1999		Sequencing	Whole gene	Z	100	Proportion method	37/60	1/0
715	171	Scorpio A AAC 1997	del C	312	104	Frameshift	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
716	172	Hirano K TLD 1997	AGC/AGG	312	104	Ser/Arg	1997	Yemen	Sequencing	Whole gene	ZHRSE	>800	Middlebrook 7H11 agar w/ pH of 6.0	33/168	1/0
717	173	Louw GE Int J Tuberc Lung Dis 2006	GAA/AAA	319	107	Gly/Lys	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
718	174	Hirano K TLD 1997	ACG/CCG	340	114	Thr/Pro	1997	Yemen	Sequencing	Whole gene	ZHR	>800	Middlebrook 7H11 agar w/ pH of 6.0	33/168	1/0
721	177	Louw GE Int J Tuberc Lung Dis 2006	CTG/GTG	346	116	Leu/Val	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
722	178	Marttila HJ AAC 1999	CTG/CGG	347	116	Leu/Arg	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
723	179	Hou L Epi Infect 2000	AAT/ACT	353	118	Asn/Thr	1996-1998	China	PCR-SSCP	Whole gene	ZHRS	1000	Proportion method, BACTEC 460	35/65	1/0
724	180	Sreevatsan S AAC 1997	TGG/CGG	355	119	Trp/Arg	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
725	181	Stavrum R PlosOne 2009	TGG/TGC	357	119	Trp/Cys	Published 2009	India	Sequencing	Whole gene	RSHE	> 100 mg/L	Proportion method	13/39	(2/0)	1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present
726	182	Lee KW J Korean Med Sci 2001	TGG/TGA	357	119	Trp/STOP	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
727	183	Portugal I AAC 2004	CTG/CCG	359	120	Leu/Pro	2000-2001	Portugal	Sequencing	Whole gene	Z		BACTEC MGIT 960	55	55
728	184	Sreevatsan S AAC 1997	CGG/CCG	362	121	Arg/Pro	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
731	187	Marttila HJ AAC 1999	GTC/GAC	374	125	Val/Asp	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
732	188	Peridgao J MDR 2008	GTC/GGC	374	125	Val/Gly	2003	Portugal	Sequencing	Whole gene	ZHRS		MGIT 960	48/58	19/0
737	193	Rodrigues V de F AAC 2005	GTC/GGC	384	128	Val/Gly	1998-2003	Brazil	Sequencing	Whole gene	Z		Proportion method and Pzase test	59	40
741	197	Hirano K TLD 1997	GTG/GGG	389	130	Val/Gly	1997	Canada	Sequencing	Whole gene	ZHRSE	>800	Middlebrook 7H11 agar w/ pH of 6.0	33/168	1/0
746	202	Hirano K TLD 1997	GGT/GAT	395	132	Gly/Asp	1997	Myanmar	Sequencing	Whole gene	Z	>800	Proportion method	33/168	1/0
747	203	Scorpio A AAC 1997	GGT/AGT	394	132	Gly/Ser	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	2/0
750	206	Marttila HJ AAC 1999	ATT/ACT	398	133	Ile/Thr	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
751	207	Morlock GP AAC 2000	ATT/AAT	398	133	Ile/Asn	1999		Sequencing	Whole gene	Z	800	Proportion method	37/60	1/0
752	208	Escalante P TuberLung Dis 1998	GCC/GTC	401	134	Ala/Val	1995-1996	Peru	Sequencing	Whole gene	ZHRP		Proportion method	40146	1/0	katG, 315, AGC/ACC; rpoB, 531, TCG/TTG;
753	209	Morlock GP AAC 2000	ACC/CCC	403	135	Thr/Pro	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
756	212	Lee KW J Korean Med Sci 2001	GAT/TAT	406	136	Asp/Tyr	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	2/0
757	213	Lee KW J Korean Med Sci 2001	GAT/AAT	406	136	Asp/Asn	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
758	214	Mestdagh M AAC 1999	GAT/CAT	406	136	Asp/His	1999	Scotland	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
760	216	Louw GE Int J Tuberc Lung Dis 2006	GAT/GGT	407	136	Asp/Gly	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
762	218	Scorpio A AAC 1997	CAT/CCT	410	137	His/Pro	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
763	219	Sreevatsan S AAC 1997	CAT/CGT	410	137	His/Arg	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	2/0
764	220	Cheng SJ AAC 2000	TGT/TCT	413	138	Cys/Ser		South korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0?
765	221	Scorpio A Nature Med 1996	TGT/TAT	413	138	Cys/Tyr		USA (Colorado)	Sequencing	Whole gene	MDR	>500ug/ml	Pzase testing by Wayne's method	39910	1/0
767	223	Cheng SJ AAC 2000	GTG/ATG	415	139	Val/Met		South korea	Sequencing	Whole gene	Z	>500	Proportion method, BACTEC 460	59/59	1/0?
768	224	Morlock GP AAC 2000	GTG/CTG	415	139	Val/Leu	1999		Sequencing	Whole gene	Z	100	Proportion method	37/60	1/0
769	225	Morlock GP AAC 2000	GTG/GGG	416	139	Val/Gly	1999		Sequencing	Whole gene	Z	>800	Proportion method	37/60	1/0
770	226	Sreevatsan S AAC 1997	GTG/GCG	416	139	Val/Ala	1996	Diverse geographical locations	Sequencing	Whole gene	Z		BACTEC 460	67/118	1/0
772	228	Cheng SJ AAC 2000	CGC/AGC	418	140	Arg/Ser			Sequencing	Whole gene	Z		Proportion method, BACTEC 460	59/59	20/0
776	232	Lee KW J Korean Med Sci 2001	CAG/TAG	421	141	Gln/STOP	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
777	233	Scorpio A Nature Med 1996	CAG/CCG	422	141	Gln/Pro		USA	Sequencing	Whole gene	MDR	>500ug/ml	Pzase testing by Wayne's method	invitro	1/0
778	234	Escalante P TuberLung Dis 1998	ACG/CCG	424	142	Thr/Pro	1995, 1996	Peru	Sequencing	Whole gene	MDR		Proportion method	40146	1/0	rpoB, 516, GAC/TAC
779	235	Hirano K TLD 1997	ACG/GCG	424	142	Thr/Ala	1997	Myanmar	Sequencing	Whole gene	ZHRSE	>800	Middlebrook 7H11 agar w/ pH of 6.0	33/168	1/0
780	236	Scorpio A AAC 1997	ACG/AAG	425	142	Thr/Lys	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
781	237	Scorpio A AAC 1997	ACG/ATG	425	142	Thr/Met	1992-1995		PCR-SSCP	Whole gene	Z	>900ug/ml	Pzase testing by Wayne's method	46/46	1/0
783	239	Lee KW J Korean Med Sci 2001	GCG/ACG	436	146	Ala/Thr	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
785	241	Hirano K TLD 1997	GCG/GTG	437	146	Ala/Val	1997	India	Sequencing	Whole gene	ZRS	>800	Proportion method	33/168	1/0
787	243	Sekiguchi JI JCM 2007	CGC/AGC	442	148	Arg/Ser	2006	Poland	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
788	244	Brown TJ JMedMicro 2000	C/A	442	148	Arg/Ser	2000	Turkey	Sequencing	Whole gene	ZHRP		BACTEC 460	13/18	1/0	C2431G(rpoB)
793	249	Morlock GP AAC 2000	ACC/AAC	458	153	Thr/Asn	1999		Sequencing	Whole gene	Z	800	Proportion method	37/60	1/0
794	250	Marttila HJ AAC 1999	AGG/GGG	460	154	Arg/Gly	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	1/0	not tested
795	251	Lemaitre N AAC 1999	GTG/GGG	464	155	Val/Gly	1987	France	Sequencing	Whole gene	ZHRE	1500		19/35	1/0
796	252	Escalante P TuberLung Dis 1998	GTG/GCG	464	155	Val/Ala	1995, 1996	Peru	Sequencing	Whole gene	ZHRES		Proportion method	40146	1/0	katG, 315, AGC/ACC; rpoB, 531, TCG/TTG;
799	255	Louw GE Int J Tuberc Lung Dis 2006	CTG/CCG	476	159	Leu/Pro	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
800	256	Lee KW J Korean Med Sci 2001	CTG/CGG	476	159	Leu/Arg	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
801	257	Marttila HJ AAC 1999	ACA/CCA	478	160	Thr/Pro	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	2/0	not tested
803	259	Marttila HJ AAC 1999	GCG/CCG	481	161	Ala/Pro	1994-1997	Russia	Sequencing	Whole gene	Z		BACTEC 460	36/44	2/0	not tested
804	260	Chan RCY JAC 2007	GGT/GAT	485	162	Gly/Asp	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	ZOREth	100mg/L	BACTEC MGIT 960	89/250	1/0	Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB)
806	262	Cheng SJ AAC 2000	ACC/AAC	503	168	Thr/Asn		Canada	Sequencing	Whole gene	ZRO	300	Proportion method, BACTEC 460	59/59	1/0
807	263	Mestdagh M AAC 1999	GCG/ACG	511	171	Ala/Thr	1999	Bangladesh	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
808	264	Sachais BS MolDiag 1998	GCG/CCG	511	171	Ala/Pro	1993-1999	USA	Sequencing	Whole gene	Z		BACTEC at pH 6.4	39856	1/0
809	265	Mestdagh M AAC 1999	GCG/GTG	512	171	Ala/Val	1999	Scotland	Sequencing	Whole gene	Z		BACTEC 460	23/62	1/0
810	266	Rodrigues V de F AAC 2005	GCG/GAG	512	171	Ala/Glu	1998-2003	Brazil	Sequencing	Whole gene	Z		Proportion method	59	40
812	268	Hirano K TLD 1997	CTG/CCG	515	172	Leu/Pro	1997	Canada	Sequencing	Whole gene	ZHRSE	>800	Proportion method	33/168	1/0
813	269	Mestdagh M AAC 1999	CTG/GCG	514-515	172	Leu/Ala	1999	Belgium	Sequencing	Whole gene	Z		BACTEC 460	23/62	2/0
815	271	Sekiguchi JI JCM 2007	ATG/GTG	523	175	Met/Val	2006	Japan	Multi-plex PCR	Whole gene	Z		Proportion method, rapid broth method	17/138	1/0
817	273	Louw GE Int J Tuberc Lung Dis 2006	AGC/CGC	535	179	Ser/Arg	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
818	274	Lee KW J Korean Med Sci 2001	GTC/TTC	538	180	Val/Phe	2001	South korea	Sequencing	Whole gene	Z		PZase test with Wayne's method	92/95	1/0
819	275	Louw GE Int J Tuberc Lung Dis 2006	GAG/GAT	543	181	Glu/Asp	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
820	276	Lemaitre N AAC 1999	TTG/TCG	545	182	Leu/Ser	1997	France	Sequencing	Whole gene	ZHRS	500-2000ug/ml		19/35	1/0
821	277	Louw GE Int J Tuberc Lung Dis 2006	AGC/ACC	554	185	Ser/Thr	2001-2002	South Africa	Sequencing	Whole gene	ZHRSEthK		BACTEC MGIT 960	115	68
822	278	Chan RCY JAC 2007	AGC/ATC	554	185	Ser/Ile	1994-2004	Hong Kong	PCR-SSCP , Sequencing	Whole gene	Z		BACTEC MGIT 960	250	89