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ISONIAZID [INH]


fbpC: Rv0129cRv0340: Rv0340iniB: Rv0341iniA: Rv0342iniC: Rv0343mabA: Rv1483inhA: Rv1484Rv1592c: Rv1592cRv1772: Rv1772ndh: Rv1854ckatG: Rv1908cfurA: Rv1909csrmR: Rv2242fabD: Rv2243kasA: Rv2245accD6: Rv2247oxyR: Rv2427aaphC: Rv2428efpA: Rv2846cfadE24: Rv3139nhoA: Rv3566cembB: Rv3795

Rv1908c

More about Rv1908c on    TBDB.org

More about Rv1908c on    TubercuList

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Codons 720 to 739:5 Mutation Codons 700 to 719:5 Mutation Codons 680 to 699:3 Mutation Codons 640 to 659:1 Mutation Codons 620 to 639:3 Mutation Codons 600 to 619:4 Mutation Codons 580 to 599:5 Mutation Codons 560 to 579:4 Mutation Codons 540 to 559:3 Mutation Codons 520 to 539:4 Mutation Codons 500 to 519:6 Mutation Codons 480 to 499:5 Mutation Codons 460 to 479:3 Mutation Codons 440 to 459:4 Mutation Codons 420 to 439:5 Mutation Codons 400 to 419:8 Mutation Codons 380 to 399:8 Mutation Codons 360 to 379:4 Mutation Codons 340 to 359:8 Mutation Codons 320 to 339:18 Mutation Codons 300 to 319:36 Mutation Codons 280 to 299:10 Mutation Codons 260 to 279:7 Mutation Codons 240 to 259:8 Mutation Codons 220 to 239:8 Mutation Codons 200 to 219:4 Mutation Codons 180 to 199:8 Mutation Codons 160 to 179:6 Mutation Codons 140 to 159:12 Mutation Codons 120 to 139:17 Mutation Codons 100 to 119:12 Mutation Codons 80 to 99:9 Mutation Codons 60 to 79:12 Mutation Codons 40 to 59:3 Mutation Codons 20 to 39:5 Mutation Codons 0 to 19:10 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
10741 Baker LV AAC 2005 ins C-1 Frameshift1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0CCC-CCG substitution at nt 723, Pro-Pro   
10752 Gagneux S PLOS Path 2006 GTG/TTG or GTG/CTG11Val/Leu             
10763 Heym B MolMicro 1995 GTG/GCG21Val/Ala1995RussiaPCR-SSCP, SequencingWhole geneMDR1Proportion method34/371/0    
10774 Cockerill FR JID 1995 CCC/TCC42Pro/Ser1995USA, JapanSequencingWhole gene 0.12Proportion method400711/0Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe   
10785 Siddiqi N AAC 2002 del C3010TRUNC 26aa1995-1998IndiaSequencingnt 3-239 & 1187-1600H,HRO,HR,HROS10ug/ml R, 1ug/ml I, 2ug/ml O 2ug/ml SProportion method74/1266/0R463L KatG, S95T gyrA, H526R rpo, H526Y rpo, D516V rpo, S531L rpo, D94A gyrA, K121K rpsL   
10796 Cockerill FR JID 1995 del 8bp 10Frameshift1995USASequencingWhole geneH>32ug/mlProportion method400711/0Ala424Val and Ala550Asp in katG.   
10807 Siddiqi N AAC 2002 ACC/GCC3111Thr/Ala1995-1998IndiaSequencing3-239,1187-1600H,R10ug/ml R, 1ug/ml IProportion method74/1261/0R463L KatG, D516G rpo   
10818 Siddiqi N AAC 2002 ACC/CCC3412Thr/Pro1995-1998IndiaSequencingnt 3-239 1187-1600H1ug/ml IProportion method74/1261/0R463L KatG   
10829 Cockerill FR JID 1995 AGC/AAC5017Ser/Asn1995USASequencingWhole geneH0.12-1ug/mlProportion method40071 Gly19Asp, Gln224Glu, Ala243Ser, Ala550Asp High confidence details 
108310 Cockerill FR JID 1995 GGC/GAC5619Gly/Asp1995USASequencingWhole geneH0.12ug/mlProportion method400710/1Pro2Ser, Ser17Asn, Gln224Glu, Ala243Ser, Ala550Asp High confidence details 
108411 Ramaswamy SV J Med Micro 2004 del85-105929-353Truncation1996-1998MexicoDirected Oligonucleotide array, Sequencingcodon 228-357H,R,E>=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml EProportion method37/501/0nt 1238; T-C rrs   
108512 Siddiqi N AAC 2002 ins A9833Truncation1995-1998IndiaSequencingnt 3-239 & 1187-1600HR,HRS10ug/ml R, 1ug/ml IProportion method74/1264/0S531W rpo, H526L rpo, R463L KatG, D516G rpo, H526R rpo   
108613 Siddiqi N AAC 2002 AAC/GAC10335Asn/Asp2002IndiaSequencing.237bp + 414bp fragmentsI,IRSO>1ug/mlProportion method74/1262/0One mutant at katG Arg463Leu; both mutant at rpoB Asp516Val.   
108714 Siddiqi N AAC 2002 del G10937TRUNC 45aa1995IndiaSequencingnt 3-239 & 1187-1600HRO,HR10ug/ml R, 1ug/ml I 2ug/ml OProportion method74/1262/0S531W rpo, S95T gyrA, L511L H526R rpo   
108815 Secondary Publication: Hazbon MH AAC 2006 TGG/TGA11438Trp/STOP             
108916 Sekigushi J JCM 2007 CTG/CAG14348Leu/Gln2007JapanSequencingWhole gene  Proportion method, BACTEC38/1381/0 -15C/T upstream of mabA   
109017 Baker LV AAC 2005 del A14950Frameshift1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0ahpC-34A   
109118 Pretorius GS AAC 1995 del CCGTCGCTGACC157-16852-57del Ala Val Ala Asp Pro1995USAPCR-SSCP, Sequencing1-221, 202-338, 319-558, 541-741, 722-942, 923-1140, 1120-1342, 1323-1526, 1507-1718, 1699-1915, 1896-2115, 2096-2310HR1.0 ug/mlProportion method39/691/0    
109219 Siddiqi N AAC 2002 GCG/ACG18161Ala/Thr1995-1998IndiaSequencingnt 3-239 & 1187-1600HRO10ug/ml R, 1ug/ml I, 2ug/ml O Proportion method74/1261/0R463L KatG, S95T gyrA, S531L rpo   
109320 Siddiqi N AAC 2002 ins C18562Truncation1995-1998IndiaSequencingnt 3-239 & 1187-1600HRS,HO,HR10ug/ml R, 1ug/ml I 2ug/ml OProportion method74/1263/0S531W rpo, K121K rpsL, S95T gyrA,H526R rpo   
109421 Rouse DA AAC 1995 GAC/GAA18963Asp/Glu1995USA, South KoreaPCR-SSCP, SequencingWhole geneH50ug/mlAbsolute concentration method.26/261/0    
109522 Marttila HJ AAC 1996 ins CCCC19565Frameshift1989-1995FinlandSequencingWhole geneH1ug/mlDisk elution method54/561/0    
109623 Cockerill FR JID 1995 GCC/ACC19365Ala/Thr1995USAPCR, RFLP, Sequencing.Whole geneH0.25ug/mlProportion method400710/1Ala66Pro and others in katG.   
109724 Cockerill FR JID 1995 GCG/CCG19666Ala/Pro1995USASequencingWhole geneH0.25ug/mlProportion method400710/1Ala65Thr, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe   
109825 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATC/AAC21271Ile/Asn             
109926 Chan RCY JAC 2007 GAC/GGC 72Asp/Gly1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
110027 Secondary Publication: Hazbon MH AAC 2006 GAC/AAC21472Asp/Lys             
110128 Siddiqi N AAC 2002 GAC/AAC?73Asp/Asn1995IndiaSequencingnt 3-239 & 1187-1600H1ug/ml IProportion method74/1261/0R463L KatG   
110229 Chan RCY JAC 2007 GAC/TAC22074Asp/Tyr1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
110330 Chan RCY JAC 2007 GAC/GGC22174Asp/Gly1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
110431 Chan RCY JAC 2007 ATG/ATA25284Met/Ile1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
110532 Gagneux S PLOS Path 2006 ACC/CCC25385Thr/Pro             
110633 Marttila HJ AAC 1998 CAG/CGG26388Gln/Arg             
110734 Cockerill FR JID 1995 TGG/TGA27090Trp/STOP1995USA, JapanSequencingWhole gene >32; catalase 5 mmProportion method400711/0none   
110835 Ramaswamy SV AAC 2003 TGG/CGG27191Trp/Arg USA, MexicoSequencing  2BACTEC radiometric method; E-test38/1211/0D3G (srmR homolog)   
110936 Gagneux S PLOS Path 2006 GAC/GGC28194Asp/Gly             
111037 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC28194Asp/Ala             
111138 Chan RCY JAC 2007 GGC/TGC?96Gly/Cys1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
111239 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGG/GAG29699Gly/Glu             
111340 Rouse et al MM 1996 CGG/CTG311104Arg/Leu1996    >500N.S.n/a100 fold reduction in peroxidase activity    
111441 Gagneux S PLOS Path 2006 CGG/CAG311104Arg/Gln             
111542 Gagneux S PLOS Path 2006 GCG/GTG317106Ala/Val             
111643 Gagneux S PLOS Path 2006 TGG/CGG or TGG/AGG319107Trp/Arg             
111744 Baker LV AAC 2005 TGG/TGA321107Trp/STOP1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0ahpC-30T   
111845 Rouse et al MM 1996 CAC/GAC322108His/Asp1996     N.Sn/a     
111946 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/GAA or CAC/GAG322,324108His/Glu             
112047 Rouse DA AAC 1995 CAC/CAG324108His/Gln1995USA, South KoreaPCR-SSCP, SequencingWhole geneH50Absolute concentration method26/261/0    
112148 Gagneux S PLOS Path 2006 GCT/GTT326109Ala/Val             
112249 Wei CJ AAC 2003 GCC/GTC329110Ala/Val2003   H        
112350 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del?113Frameshift?             
112451 Lavender C AAC 2005 GAC/GCC350117Asp/Ala2001-2003AustraliaSequencingWhole geneHR0.4 ug/ml IBACTEC 52/1041/0    
112552 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del?120Frameshift?             
112653 Heym B MolMicro 1995 del358-369120-123del1995YugoslaviaPCR-SSCP, SequencingWhole geneH Proportion method34/372/0    
112754 Gagneux S PLOS Path 2006 GGC/TGC361121Gly/Cys             
112855 Marttila HJ AAC 1998 GGC/GTC362121Gly/Val1993-1995RussiaSequencing.Whole geneHRN/AProportion method24/271/0Asp516Val in rpoB   
112956 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del?122Frameshift?             
113057 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del?123Frameshift?             
113158 Ramaswamy SV AAC 2003 ins G372124Frameshift USA, MexicoSequencing  >256BACTEC 460, E-test38/1211/0G-9A (oxyR-ahpC)   
113259 Chan RCY JAC 2007 GGC/TGC373125Gly/Cys1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
113360 Heym B MolMicro 1995 ins CAT373-375125ins His1995YugoslaviaPCR-SSCP, SequencingWhole geneH Proportion method34/371/0    
113461 Cockerill FR JID 1995 ATG/ATT, ATG/ATC or ATG/ATA378126Met/Ile1995USA, JapanSequencingWhole gene .025; catalase 14 mmProportion method400711/0A65T; A66P; A243S; N258S; A264T; Y337F   
113562 Chan RCY JAC 2007 CAG/CCG380127Gln/Pro1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
113663 Fang Z JCM 1999 CGG/CCG384128Arg/Pro1990-1997United KingdomPCR-SSCP, Sequencing2268-2288&2595-2615, 2781-2801&3115-3135, 3366-3386& 3633-3653, 3661-3681& 3973-3993H,E,R,P,Rifa,Cip,Ami,S,Proth BACTEC 46010/7151/0Leu511Pro rpoB   
113764 Hazbon MH AAC 2006 AAC/CAC412138Asn/His2006USA, SpainHP asay, molecular beacon assay, Sequencing H0.2ug/ml proportion method, 0.1 for BACTEC methodsProportion method, BACTEC MGIT 960, BACTEC 460403/11111/0    
113865 Hazbon MH AAC 2006 AAC/GAC412138Asn/Asp2006USA, SpainHP asay, molecular beacon assay, Sequencing H0.2ug/ml proportion method, 0.1 for BACTEC methodsProportion method, BACTEC MGIT 960, BACTEC 460403/11112/0    
113966 Hazbon MH AAC 2006 AAC/AGC413138Asn/Ser2006USA, SpainHP asay, molecular beacon assay, Sequencing H0.2ug/ml proportion method, 0.1 for BACTEC methodsProportion method, BACTEC MGIT 960, BACTEC 460403/11111/0    
114067 Morlock GP AAC 2003 AAC/ACC413138Asn/Thr2003USA, Russia, BrazilSequencingWhole geneH>32ug/mlMicroplate alamar blue assay method17/411/0    
114168 Wei CJ AAC 2003 GCC/CCC415139Ala/Pro2003            
114269 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/GCC?418-419?140Ser/Ala             
114370 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/AAC419140Ser/Asn2006USA, SpainHP asay, molecular beacon assay, Sequencing  0.2ug/ml proportion method, 0.1 for BACTEC methodsProportion method, BACTEC MGIT 960, BACTEC 460403/11119/0  High confidence details 
114471 Secondary Publication: Hazbon MH AAC 2006 AGC/GGC418140Ser/Gly             
114572 Hai Hua Lin TubercRespirDis 2007 AGC/AGA420140Ser/Arg2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0katG N238K High confidence details 
114673 Sekigushi J JCM 2007 TTG/TTC423141Leu/Phe2007Japan, PolandSequencingWhole gene  Proportionmethod, BACTEC MGIT 96038/1382/0    
114774 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC425142Asp/Ala             
114875 Gagneux S PLOS Path 2006 AAG/ACG428143Lys/Thr             
114976 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CTG/GCG443148Leu/Ala             
115077 Rouse et al MM 1996 CTG/CGG443148Leu/Arg1996     N.S.n/a     
115178 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CCG/GCG?? See NoteSee Note150Leu/Ala Error? See Note             
115279 Marttila HJ AAC 1998 TAC/TCC464155Tyr/Ser1993-1995RussiaSequencing.Whole geneHRSK1 ug/ml I, 5 ug/ml R Proportionmethod24/271/0Arg463Leu katG, Ser 531Leu rpoB   
115380 Gagneux S PLOS Path 2006 TAC/TGC464155Tyr/Cys1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502413   
115481 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCA/TTA479160Ser/Leu             
115582 Gagneux S PLOS Path 2006 GCG/ACG484162Ala/Thr             
115683 Cockerill FR JID 1995 GGC/GCC506169Gly/Ala1995USASequencing.Whole geneH1ug/mlProportion method400711/0Pro2Ser, Ser17Asn, Met126Ile, Gln224Glu, Ala264Val, Ala281Val, Try337Cys, Arg463Leu   
115784 Secondary Publication: Hazbon MH AAC 2006 GCG/ACG514172Ala/Thr2006USA, SpainHP asay, molecular beacon assay, Sequencing H0.2ug/ml proportion method, 0.1 for BACTEC methodsAgar Proportion method, BACTEC MGIT 960, BACTEC 460403/11112/0    
115885 Chan RCY JAC 2007 GCG/GTG515172Ala/Val1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
115986 Chan RCY JAC 2007 ATG/ATA528176Met/Ile1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502413   
116087 Secondary Publication: Hazbon MH AAC 2006 ACG/AAG539180Thr/Lys             
116188 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ACG/???See Note180Thr/Cys             
116289 Chan RCY JAC 2007 GGC/GTC557186Gly/Val1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
116390 Chan RCY JAC 2007 GGC/CAC556-557186Gly/His1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
116491 Baker LV AAC 2005 TGG/CGG571191Trp/Arg1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0    
116592 Chan RCY JAC 2007 del G572191Frameshift1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
116693 Morlock GP AAC 2003 G/A583195Glu/Lys2003USASequencingWhole geneEth1Microplate alamar blue assay17/410/1nt 280 T/G inh ORF   
116794 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TGG/TGA594198Trp/STOP             
116895 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AAG/TAG598200Lys/STOP             
116996 Abe C JCM 2008   204Trp/ArgPublished in 2008JapanSequencingWhole geneH MGIT 96096/961/0    
117097 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins?217Frameshift?             
117198 Chan RCY JAC 2007 AAC/AAA654218Asn/Lys1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
117299 Cockerill FR JID 1995 CAG/GAG670224Gln/Glu1995USA, JapanSequencingWhole gene 1; catalase 8 mmProportionmethod 1/0Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Ala264Val, Ala281Val, Try337Cys, Arg463Leu   
1173100 Cockerill FR JID 1995 CAG/GAG670224Gln/Glu1995USASequencingWhole geneH<0.12-1ug/mlProportion method 39815Ala424Glu, Pro429Ser   
1174101 Ghiladi RA J Am Chem Soc 2005 TAC/TTC686229Tyr/Phe             
1175102 Chan RCY JAC 2007 GTG/GCG689230Val/Ala1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
222103 Baker LV AAC 2005 GGG/GAG701234Gly/Glu1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0    
223104 Chan RCY JAC 2007 GGG/AGG700234Gly/Arg1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
224105 Chan RCY JAC 2007 AAC/ACC707236Asn/Thr1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
225106 Hai Hua Lin TubercRespirDis 2007 AAC/AAG714238Asn/Lys2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0katG S140R   
226107 Baker LV AAC 2005 CCC/CCG723241Pro/Pro1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3782/0    
227108 Cockerill FR JID 1995 GCC/TCC727243Ala/Ser1995USA, JapanSequencingWhole gene 0.12; catalase 28mmMiddlebrook 7H11 agar; 1% Proportion method 1/0Pro2Ser, Ser17Asn, Gly19Asp, Gln224Glu, Ala550Asp   
228109 Ramaswamy SV J Med Micro 2004 CGC/TGC745249Arg/Cys1996-1998MexicoDirected Oligonucleotide array, Sequencingcodon 228-357HRSE>=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml EProportion method37/502/0His445Tyr rpoB, Lys43Arg rpsL, Met306Ile embB   
229110 Gagneux S PLOS Path 2006 ACG/ATG752251Thr/Met             
230111 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TTT/CTT754252Phe/Leu             
231112 Sekigushi J JCM 2007 ATG/ACG770257Met/Thr2007Japan, PolandMultiplex SequencingWhole gene  Middlebrook 7H10 agar medium method Ogawa egg based medium method, Rapid broth method(BACTEC)38/1381/0R463L V780P katG, -15C/T upstream of mabA   
232113 Lavender C AAC 2005 ATG/ATT771257Met/Ile2001-2003AustraliaMultiplex allele specific PCR AssayWhole geneHR0.1ug/ml I, 1ug/ml RBACTEC MGIT96052/1041/0    
233114 Cockerill FR JID 1995 AAC/AGC773258Asn/Ser1995USASequencing.Whole geneH0.25ug/mlProportion method 0/1Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Ala264Thr, Tyr337Phe   
234115 Rouse DA AAC 1995 ACA/AGA785262Thr/Arg1995USA, South KoreaPCR-SSCP, SequencingWhole geneH1 ug/mlAbsolute concentration method26/261/0    
235116 Cockerill FR JID 1995 GCG/ACG790264Ala/Thr1995USA, JapanSequencingWhole gene 0.25; catalase 14mmMiddlebrook 7H11 agar; 1% Proportion method 1/0Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Tyr337Phe   
236117 Chan RCY JAC 2007 del G 268Frameshift1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
237118 Pretorius GS AAC 1995 ACC/GCC820275Thr/Ala1995South Africa, SwitzerlandPCR-SSCP, SequencingWhole gene?HR,HRSEEryB10 & >2.5 ug/mlAgar dilution method39/692/0    
238119 Heym B MolMicro 1995 ACC/CCC823275Thr/Pro1995FrancePCR-SSCP, SequencingWhole geneHMDR> 10 ug/mlProportion method34/371/0    
239120 Ramaswamy SV J Med Micro 2004 ACC/TCC823275Thr/Ser1996-1998MexicoDirected Oligonucleotide array, Sequencingcodon 228-357HR>=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml EProportion method37/501/0His445Asp rpoB,   
240121 Morlock GP AAC 2003 GGC/GAC836279Gly/Asp2003BrazilSequencingfragment encompassing codons 249 to 342HEth>32 I, >200 EthMicroplate alamar blue assay17/411/0D55/A ethA,L44L inhA ORF, C(-15)T inhA regulator High confidence details 
241122 Gagneux S PLOS Path 2006 CCG/CAT or CCG/CAC839-840280Pro/His             
242123 Cockerill FR JID 1995 GCC/GTC842281Ala/Val1995USASequencingWhole geneH1ug/mlProportion method 1/0Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Gln224Glu, Ala264Val, Try337Cys, Arg463Leu   
243124 Abe C JCM 2008 GGC/GAC854285Gly/AspPublished in 2008JapanSequencingWhole geneH MGIT 96096/961/0  High confidence details 
244125 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins?289Frameshift?             
245126 Chan RCY JAC 2007 GAG/GAC867289Glu/Asp1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
246127 Fang Z JCM 1999 GCT/CCT871291Ala/Pro1990-1997United KingdomPCR-SSCP, Sequencing HR BACTEC 10/7151/0His 526Tyr rpoB   
247128 Sekigushi J JCM 2007 CAG/CCG884295Gln/Pro2007PolandSequencingWhole gene  Proportion method, BACTEC38/1381/0    
248129 Sekigushi J JCM 2007 GGC/GTC890297Gly/Val2007PolandSequencingWhole gene  Proportion method, BACTEC38/1381/0    
249130 Chan RCY JAC 2007 GGC/TGC895299Gly/Cys1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502411   
250131 Huang WL JCM 2009 GGC/GCC896299Gly/Ala2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
251132 Lee ASG AAC 1999 TGG/TAA or TGG/TAG or TGG/TGA 300Trp/STOP1994-1996SingaporeSequencingWhole geneH0.1 ug/mlBACTEC 460160/192     
252133 Marttila HJ AAC 1996 TGG/GGG898300Trp/Gly1989-1995FinlandSequencingWhole geneH1 ug/mlDisk elution method54/561/0    
253134 Gagneux S PLOS Path 2006 ins T901-902301Frameshift             
254135 Cockerill FR JID 1995 AGC/AGG906302Ser/Arg1995USASequencingWhole geneH8ug/mlProportion method400711/0Ser315Thr and Arg463Leu in katG.   
255136 Bolotin S JAC 2009 TAT/TCT911304Tyr/Ser1999-2001CanadaSequencingcodon 250-500H, HR MGIT 960154/5041/0    
256137 Bostanabad SZ Tuberk Torak 2007 GGC/GCC913305Gly/Ala2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/423/0Most had 1-4 other katG mutations (most often in codon 315).   
257138 Bostanabad SZ Tuberk Torak 2007 GGA/CGA919307Gly/Arg2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/421/0Most had 1-4 other katG mutations (most often in codon 315).   
258139 Bostanabad SZ Tuberk Torak 2007 GGA/GCA920307Gly/Ala2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
259140 Ramaswamy SV J Med Micro 2004 GGA/GAA920307Gly/Glu1996-1998MexicoDirected Oligonucleotide array, Sequencingcodon 228-357HRSE>=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml EProportion method37/501/0Ser450Leu rpoB,   
260141 Khadka DK Southest Asian J Trop Med Public Health 2007 ACC/CCC922308Thr/Pro2007BangkokPCR-SSCP, Sequencing894 bp fragment encompassing codons 254 to 549HRSEO  29/301/0Arg463Leu katG, C(-15)T inhA   
261142 Bostanabad SZ Tuberk Torak 2007 GGT/GTT926309Gly/Cys2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
262143 Bostanabad SZ Tuberk Torak 2007 GGT/GCT926309Gly/Ser2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
263144 Kim SY Diagn Micro Inf Dis 2003 GGT/GAT926309Gly/Asp200-2002South KoreaPCR-SSCP, Sequencing210 bp fragment spanning codon 315HR0.2 ug/ml I 40 ug/ml RProportion method71/972/0inhA Ribosomal binding site C/T   
264145 Bostanabad SZ Tuberk Torak 2007 GGT/GTC926-927309Gly/Phe2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
265146 Huang WL JCM 2009 del A928-929310Frameshift2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
266147 Bostanabad SZ Tuberk Torak 2007 GAC/TAC931311Asp/Tyr2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
267148 Bostanabad SZ Tuberk Torak 2007 GAC/TTC931-932311Asp/Phe2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
268149 Chan RCY JAC 2007 GAC/GGC932311Asp/Gly2007Hong KongPCR-SSCP, Sequencing703 bp fragmentHEP1ug/ml I, 4ug/ml E, 100ug/ml PAbsolute concentration method, BACTEC MGIT 960241/3021/0574Ser/Leu rpoB   
269150 Zenteno-Cuevas R MemInstOswaldCruz 2009 GAC/GAG933311Asp/Glu2007MexicoSequencingcodon 240-390 of katGHREZN.S.BACTEC 46017/251/0katG S315T   
270151 Bostanabad SZ Tuberk Torak 2007 ACC/AAC941314Ser/Asn2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
271152 Bostanabad SZ Tuberk Torak 2007 ACC/ACG941-942314Ser/Thr2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
272153 Haas WA AAC 1997 AGC/CGC943315Ser/Arg1997South AfricaPCR-RFLP894 bp central fragment of katG?H  124/2121/0    
273154 Marttila HJ AAC 1996 AGC/CTA943315Ser/Leu1989-1995FinlandSequencingWhole geneHS>1ug/mlDisk elution method.17/191/0katG Pro501Ala.   
274155 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/GGC943315Ser/Gly             
275156 Musser JM JID 1996 AGC/ACC944315Ser/Thr           High confidence details 
276157 Haas WA AAC 1997 AGC/ATC944315Ser/Ile1997Sierra Leone, LesothoPCR-RFLP892 bp central fragmentHRSEth,H  124/2124/0  High confidence details 
277158 Haas WA AAC 1997 AGC/AAC944315Ser/Asn1997Free state, Gauteng, Sierra leonePCR-RFLP890 bp fragmentH,HRE,HR  124/2129/0  High confidence details 
278159 Heym B MolMicro 1995 AGC/ACC944315Ser/Thr1995Mali Ivory coast, FrancePCR-SSCP, SequencingWhole geneH1 in 4 and >5 in 1Proportional method34/375/0  High confidence details 
279160 Marttila HJ AAC 1996 AGC/ACA944-945315Ser/Thr1989-1995FinlandSequencingWhole geneHS,HRS1 ug/ml for I Disk elution method.54/562/0 nt1501G/C katG in one High confidence details 
280161 Gagneux S PLOS Path 2006 AGC/ACG944-945315Ser/Thr             
281162 Lipin MY CMI 2007 AGC/AGA945315Ser/Arg1998-2001RussiaSequencingnt 872-1568HRS1 ug/ml I, 5 ug/ml S, 20ug/ml RAbsolute concentration method217/2172/0335 /GTC katG in one High confidence details 
282163 Secondary Publication: Hazbon MH AAC 2006 AGC/AGG945315Ser/Arg             
283164 Bostanabad SZ Tuberk Torak 2007 GGC/AGC946316Gly/Ser2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/4218/0Most had 1-4 other katG mutations (most often in codon 315).   
284165 Secondary Publication: Hazbon MH AAC 2006 GGC/GAC947316Gly/Asp           High confidence details 
285166 Chan RCY JAC 2007 ATC/CTC949317Ile/Leu1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502412   
286167 Zenteno-Cuevas R MemInstOswaldCruz 2009 GAG/GTA953-954318Gly/Val2007MexicoSequencingcodon 240-390 of katGHRSEZN.S.BACTEC 46017/251/0katG S315T   
287168 Chan RCY JAC 2007 TGG/CGG961321Trp/Arg1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502413   
288169 Bostanabad SZ Tuberk Torak 2007 TGG/TAG961321Trp/STOP2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
289170 Bostanabad SZ Tuberk Torak 2007 TGG/TTG962321Trp/Leu2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
290171 Bostanabad SZ Tuberk Torak 2007 TGG/TCC962-963321Trp/Ser2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/421/0Most had 1-4 other katG mutations (most often in codon 315).   
291172 Bostanabad SZ Tuberk Torak 2007 TGG/TGT963321Trp/Cys2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/421/0Most had 1-4 other katG mutations (most often in codon 315).   
292173 No publication listed ACC/CCC970324Thr/Pro             
293174 Musser JM JID 1996 TGG/GGG982328Trp/Gly1996 SequencingWhole geneHR>=1ug/ml for IProportion method 34/461/0    
294175 Haas WA AAC 1997 TGG/TTG983328Trp/Leu1997Free state, Lesotho, Eastern Cape, Natal, Swaziland, GautengPCR-RFLP894 bp central fragment of katGH  124/2121/0    
295176 Boonaiam S CMI 2009 TGG/TCG984328Trp/Ser2005-2006ThailandSequencingWhole geneMDR>=1ug/ml for IDisk elution method160/1701/0    
296177 Haas WA AAC 1997 TGG/TGC984328Trp/Cys1997Free state, Lesotho, Eastern Cape, Natal, Swaziland, GautengPCR-RFLP894 bp central fragment of katGH  124/2121/0    
297178 Bostanabad SZ Tuberk Torak 2007 TGG/TGT984328Trp/Cys2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/424/0Most had 1-4 other katG mutations (most often in codon 315).   
298179 Zenteno-Cuevas R MemInstOswaldCruz 2009 AGT/TGT991331Ser/Cys2007MexicoSequencingcodon 240-390 of katGHRSN.S.BACTEC 46017/251/0katG S315T   
299180 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998  See Note334Ile/Thr Error             
300181 Rouse DA AAC 1995 ATC/ACC1004335Ile/Thr             
301182 Lipin MY CMI 2007 ATC/GTC1003335Ile/Val1998-2001RussiaSequencingnt 872-1568HRS1 ug/ml I, 5 ug/ml S, 20ug/ml RAbsolute concentration method217/2171/0315 AGC/AGA katG   
302183 Lee ASG AAC 1999 CTG/CGG1007336Leu/Arg             
303184 Cockerill FR JID 1995 TAC/TTC1010337Tyr/Phe1995USAPCR, RFLP, Sequencing.Whole geneH0.25ug/mlProportion method  Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr   
304185 Cockerill FR JID 1995 TAC/TGC1010337Tyr/Cys1995USAPCR, RFLP, Sequencing.Whole geneH1ug/mlProportion method 1/0Arg429Leu, Trp505Arg, Met609Ile   
305186 Morlock GP AAC 2003 TGG/TCG1022341Trp/Ser2003BrazilSequencingfragment encompassing codons 249 to 342HEth5o Eth, >32 IMicroplate alamar blue assay17/411/04463S ethA, C(-15)T inhA regulator   
306187 Gagneux S PLOS Path 2006 AAG/ACG1034345Lys/Thr             
307188 Chan RCY JAC 2007 del G 346Frameshift1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502412   
308189 Rouse et al MM 1996 GCT/ACT1048350Ala/Thr1996     N.S.n/a     
309190 Rouse DA AAC 1995 GCT/TCT1048350Ala/Ser1995 PCR SSCP Whole geneH1 ug/mlAbsolute concentration method26/261/0    
310191 Boonaiam S CMI 2009 CAA/TAA1054352Gln/STOP2005-2006ThailandSequencingWhole geneMDR>=1ug/ml for IDisk elution method160/1701/0    
311192 Bostanabad SZ Tuberk Torak 2007 GAC/CAC1069357Asp/His2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/421/0Most had 1-4 other katG mutations (most often in codon 315).   
312193 Bostanabad SZ Tuberk Torak 2007 GAC/AAC1069357Asp/Asn2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/421/0Most had 1-4 other katG mutations (most often in codon 315).   
313194 Huang WL JCM 2009 GCC/GAC1082361Ala/Asp2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
314195 Huang WL JCM 2009 del T1091364Frameshift2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
315196 Huang WL JCM 2009 CTG/CCG1133378Leu/Pro2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
316197 Huang WL JCM 2009 GCC/GTC1136379Ala/Val2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
317198 Chan RCY JAC 2007 ACT/ATT1139380Thr/Ile1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502412   
318199 Rouse et al MM 1996 GAC/GGC1142381Asp/Gly1996     N.S.n/a     
319200 Gagneux S PLOS Path 2006 CTG/CGG1151384Leu/Arg             
320201 Chan RCY JAC 2007 ACT/ATT1169390Thr/Ile1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502412   
321202 Sekigushi J JCM 2007 ins CTA1170390ins Leu2007JapanSequencingWhole gene  Proportion method, BACTEC38/1382/0    
322203 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATC/AAC1178393Ile/Asn             
323204 Gagneux S PLOS Path 2006 ACG/GCG1180394Thr/Ala             
324205 Secondary Publication: Hazbon MH AAC 2006 TGG/TAG1191397Trp/STOP             
325206 Huang WL JCM 2009 del C 401Frameshift2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
326207 Pretorius GS AAC 1995 GCC/CGC1225-1226409Ala/Arg1995South AfricaPCR-SSCP, Sequencing HRSEryB2.5 ug/mlAgar dilution method39/691/0    
327208 Chan RCY JAC 2007 GCC/GAC1226409Ala/Asp1994-2004Hong KongPCR-SSCP, SequencingWhole geneN.S. Absolute concentration method2502412   
328209 Huang WL JCM 2009 TAC/CAC1237413Tyr/His2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
329210 Bolotin S JAC 2009 AAG/AAC1242414Lys/Asn1999-2001CanadaSequencingcodon 250-500H, HR MGIT 960154/5041/0    
330211 Ghiladi RA J Am Chem Soc 2005 CGA/CTA1253418Arg/Leu             
331212 Mo L Microb Drug Res 2004 CGA/CAA1253418Arg/Gln             
332213 Huang WL JCM 2009 GAC/CAC1255419Asp/His2007-2008TaiwanSequencingN.S.242MDRN.S.MGIT 960242/2721/0not mentiond   
333214 Cockerill FR JID 1995 GCG/GAG1271424Ala/Glu1995USAPCR, RFLP, Sequencing.Whole geneH<0.12ug/mlProportion method 0/1Gln224Glu and Pro429Ser in katG.   
334215 Cockerill FR JID 1995 GCG/GTG1271424Ala/Val1995USAPCR, RFLP, Sequencing.Whole geneH>32ug/mlProportion method 1/08-bp deletion in codon 10 + Ala550Asp in katG.   
335216 Cockerill FR JID 1995 CCG/TCG1285429Pro/Ser1995USAPCR, RFLP, Sequencing.Whole geneH<0.12ug/mlProportion method 0/1Gln224Glu and Ala 424Glu in katG.   
336217 Ramaswamy SV AAC 2003 CAG/TAG1300434Gln/STOP USA, MexicoSequencing  >256BACTEC radiometric method (0.1ug/ml); E-test38/1211/0V163I (Rv0340)   
337218 Zhang M J Clin Microb 2005 ins A1329438Frameshift2005ChinaIS6110-based RFLP; Sequencing.Whole geneH BACTEC MGIT 9601/871/0Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA.   
338219 Hai Hua Lin TubercRespirDis 2007 GCG/ACG1330444Ala/Thr2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0None   
339220 Doustdar F MDR 2008 CTC/TTC1345449Leu/Phe2005-2006IranSequencing250bp around 315 and 212 bp around 463, 238bp of inhA and 293bp of ahpCHN.S.Proportion method48/931/0None   
340221 Bostanabad SZ Tuberk Torak 2007 GAG/CGA1360454Glu/Arg2004-2005BelarusPCR, Sequencing.209-bp segment.H>1ug/mlProportion method, BACTEC42/422/0Most had 1-4 other katG mutations (most often in codon 315).   
341222 Bolotin S JAC 2009 AGC/ATC1370457Ser/Ile1999-2001CanadaSequencingcodon 250-500H, HR MGIT 960154/5041/0  High confidence details 
342223 Hai Hua Lin TubercRespirDis 2007 ATC/ACC1385462Ile/Thr2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0inhA -15 (C/T)   
343224 Heym B MolMicro 1995 CGG/CTG1389463Arg/Leu             
344225 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TGG/TGA1431477Trp/STOP             
345226 Baker LV AAC 2005 CGT/AGT1450484Arg/Ser1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0    
346227 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGT/GTT1454485Gly/Val             
347228 Marttila HJ AAC 1996 G/C1464488Lys/Asn1989-1995FinlandPCR, Sequencing.Whole geneH>1ug/mlDisk elution method.17/191/0katG Gln295STOP   
348229 Baker LV AAC 2005 CGC/TGC1469490Arg/Cys1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0    
349230 Lavender C AAC 2005 GGC/TGC1471491Gly/Cys2001-2003AustraliaMultiplex allele specific PCR assayWhole geneH0.4 ug/mlBACTEC MGIT960 method52/1041/0    
350231 Hai Hua Lin TubercRespirDis 2007 CAA/CAT1506502Gln/His2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0inhA -15 (C/T)   
351232 Abe C JCM 2008 TGG/TCG1513505Trp/SerPublished in 2008JapanSequencingWhole geneH MGIT 96096/961/0    
352233 Cockerill FR JID 1995 TGG/CGG1513505Trp/Arg1995USAPCR, RFLP, Sequencing.Whole geneH>32ug/mlProportion method 1/0Tyr337Phe, Arg429Leu, Met609Ile   
353234 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ??511Frameshift             
354235 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ??513Frameshift             
355236 Zhang M J Clin Microb 2005 CGC/TGC1543515Arg/Cys2005ChinaSequencing.Whole geneH8ug/mlBACTEC MGIT 96087/1371/0Arg463Leu in katG.   
356237 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ??521Frameshift             
357238 Zhang M J Clin Microb 2005 ins 64bp1559521Frameshift2005ChinaSequencing.Whole geneH>256ug/mlBACTEC MGIT 96087/1371/0Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA.   
358239 Marttila HJ AAC 1996 CAG/CCG1574525Gln/Pro1989-1995FinlandSequencingWhole geneH0.4 ug/ml for Idisk elution method54/561/0    
359240 Ramaswamy SV AAC 2003 AAC/GAC1585529Asn/Asp2003USA, Mexico, Central America, Southeast Asia, and Africa.SequencingWhole geneHN/AE-Test38/1241/0katG Trp397Tyr, no other mutations in the 19 genes sequenced.   
360241 Cockerill FR JID 1995 GCC/GAC1649550Ala/Asp1995USASequencing.Whole geneH0.12->32ug/mlProportion method  R strain also Ala424Val; S strain also Gln224Glu, Ala243Ser.   
361242 Hai Hua Lin TubercRespirDis 2007 GCC/GGC1652551Ala/Gly2004South KoreaSequencingWhole geneMDRN.S.N.S29/291/0None   
362243 Secondary Publication: Hazbon MH AAC 2006 del C1667556Frameshift             
363244 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TTC/TCC1700567Phe/Ser             
364245 Gagneux S PLOS Path 2006 GAT/AAT1717573Asp/Asn             
365246 Secondary Publication: Hazbon MH AAC 2006 GCG/GAG1721574Ala/Glu             
366247 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GCG/GTG1721574Ala/Val             
367248 Secondary Publication: Hazbon MH AAC 2006 CTG/ATG1759587Leu/Ile             
368249 Heym B MolMicro 1995 CTG/ATG1759587Leu/Met1995N.S.PCR-SSCP, SequencingWhole geneH>5 ug/mlProportion method39/391/0    
369250 Marttila HJ AAC 1996 CTG/CCG1760587Leu/Pro1989-1995FinlandSequencingWhole geneH0.4ug/mldisk elution method54/561/0    
370251 Cockerill FR JID 1995 CCC/ACC1765589Pro/Thr1995USAPCR, RFLP, Sequencing.Whole geneH32ug/mlProportion method400711/0Arg429Leu, Ala264Thr in katG.   
371252 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGC/GAC1778593Gly/Asp           High confidence details 
372253 Gagneux S PLOS Path 2006 GAG/AAG1819607Glu/Lys             
373254 Cockerill FR JID 1995 ATG/ATT, ATG/ATC or ATG/ATA1827609Met/Ile1995USAPCR, RFLP, Sequencing.Whole geneH<0.12-32ug/mlProportion method  The 2 R isolates also had Arg463Leu + one other mutation each; the S isolate had no other mutations.   
374255 Marttila HJ AAC 1996 ins AC1849617Frameshift1989-1995FinlandSequencingWhole geneH1 ug/mldisk elution method54/561/0    
375256 Wei CJ AAC 2003 CTC/CCC1856619Leu/Pro2003            
376257 Rouse DA AAC 1995 GGC/AGC1888629Gly/Ser1995 PCR SSCP analysisWhole geneH1ug/mlAbsolute concentration method26/261/0    
377258 Wei CJ AAC 2003 CTC/TTC1900634Leu/Phe2003            
378259 Gagneux S PLOS Path 2006 GCA/GAA1907636Ala/Glu             
379260 Gagneux S PLOS Path 2006 CTG/CCG1958653Leu/Pro             
380261 Zhang M J Clin Microb 2005 GGC/CGC2053685Gly/Arg2005ChinaSequencing.Whole geneH2ug/mlBACTEC MGIT 9601/871/0Ser315Thr in katG.   
381262 Pretorius GS AAC 1995 GAC/GCC2084695Asp/Ala1995South AfricaPCR-SSCP, Sequencing HRS40Agar dilution method39/691/0    
382263 Baker LV AAC 2005 GGG/GAG2096699Gly/Gln1998United KingdomDirected Oligonucleotide array, SequencingWhole geneH,HS,HE,HSE,MDRratio>=4Resistance ratio method202/3781/0    
383264 Marttila HJ AAC 1996 TCC/CCC2098700Ser/Pro1989-1995FinlandSequencingWhole geneH1 ug/mldisk elution method54/561/0    
384265 Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GTC/GCC2129710Val/Ala             
385266 Secondary Publication: Hazbon MH AAC 2006 GCC/CCC2137713Ala/Pro             
387268 Rouse DA AAC 1995 GCG/CCG2146716Ala/Pro1995USA, South KoreaPCR-SSCPWhole geneHRP50ug/mlAbsolute concentration method26/261/0    
386267 Secondary Publication: Hazbon MH AAC 2006 CAG/CCG2150717Gln/Pro             
388269 Ramaswamy SV J Med Micro 2004 GCC/GAC2180727Ala/Asp1996-1998MexicoDirected Oligonucleotide array, Sequencingcodon 228-357HRS>=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml EProportion method37/501/0Ser450Leu rpoB, nt491C/T rrs, Met306Ile embB   
389270 Gagneux S PLOS Path 2006 TGG/TGT or TGG/TGC2184728Trp/Cys             
390271 Gagneux S PLOS Path 2006 del GAC2203-2205735del Asp             
391272 Gagneux S PLOS Path 2006 GAC/AAC2203735Asp/Asn             
392273 Wei CJ AAC 2003 GAC/GCC2204735Asp/Ala2003            

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