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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0006

More about Rv0006 on    TBDB.org

More about Rv0006 on    TubercuList

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Codons 100 to 109:2 Mutation Codons 90 to 99:11 Mutation Codons 80 to 89:3 Mutation Codons 70 to 79:1 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
1261 Shi R JCM 2006 GCC/TCC22074Ala/Ser2002-2003ChinaSequencing 227bp QRDR gyrAOFXOFL 2-32Absolute concentration method 87/10910/0gyrA: Asp94Gly High confidence details 
1294 Von Groll A AAC 2009 GAC/AAC26589Asp/AsnPublished 2006 N.S.Sequencingnt 247-282 of gyrA Resistant to: sparfloxacin, gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ofloxacin, enoxacin, temafloxacin, flumequine, oxolinic acid, nalidixic acid, pipemidic acid; and to coumarin. 2x to 16x higher than WT (H37Rv) MICs for the same drugs.Proportion method 399385/0N.S. High confidence details 
1305 Takiff HE AAC 1994 GCG/GTG26990Ala/ValPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4-8BACTEC 4603/543/0gyrA: Ser95Thr High confidence details 
1327 Takiff HE AAC 1994 TCG/CCG27191Ser/ProPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
1338 Takiff HE AAC 1994 GAC/AAC28094Asp/AsnPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
1349 Takiff HE AAC 1994 GAC/CAC28094Asp/HisPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
13611 Takiff HE AAC 1994 GAC/TAC28094Asp/TyrPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4602/542/0gyrA: Ser95Thr High confidence details 
13712 Takiff HE AAC 1994 GAC/GGC28194Asp/GlyPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4605/545/0gyrA: Ser95Thr High confidence details 
13813 Takiff HE AAC 1994 GAC/GCC28194Asp/AlaPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
14116 Kam KM Microb Drug Res 2006 CCC/CAC305102Pro/His           High confidence details 

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