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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0006

More about Rv0006 on    TBDB.org

More about Rv0006 on    TubercuList

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Codons 100 to 109:2 Mutation Codons 90 to 99:11 Mutation Codons 80 to 89:3 Mutation Codons 70 to 79:1 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
1261 Shi R JCM 2006 GCC/TCC22074Ala/Ser2002-2003ChinaSequencing 227bp QRDR gyrAOFXOFL 2-32Absolute concentration method 87/10910/0gyrA: Asp94Gly High confidence details 
1272 Aubry A AAC 2006 ACC/GCC23880Thr/AlaPublished 2006FranceSequencingQRDRs on gyrA and gyrBThe Thr80Ala mutants are resistant to all 5 drugs. The Thr80Ala + Ala90Gly double mutants are hypersusceptible to all 5 drugs, with MICs significantly lowered compared to H37Rv. Proportion method 14/15Single mutants: 2/0. Double mutants: 0/4.gyrA: Ala90Val   
1283 Matrat S AAC 2006 Dec GGC/GCC26388Gly/AlaPublished 2006 N.S.Sequencingnt 247-282 of gyrA Resistant to: sparfloxacin, gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ofloxacin, enoxacin, temafloxacin, flumequine, oxolinic acid, nalidixic acid, pipemidic acid; and to coumarin. 2x to 16x higher than WT (H37Rv) MICs for the same drugs.Proportion method 399385/0N.S.   
1294 Von Groll A AAC 2009 GAC/AAC26589Asp/AsnPublished 2006 N.S.Sequencingnt 247-282 of gyrA Resistant to: sparfloxacin, gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ofloxacin, enoxacin, temafloxacin, flumequine, oxolinic acid, nalidixic acid, pipemidic acid; and to coumarin. 2x to 16x higher than WT (H37Rv) MICs for the same drugs.Proportion method 399385/0N.S. High confidence details 
1305 Takiff HE AAC 1994 GCG/GTG26990Ala/ValPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4-8BACTEC 4603/543/0gyrA: Ser95Thr High confidence details 
1316 Aubry A AAC 2006 GCG/GGG26990Ala/GlyPublished 2006FranceSequencingQRDRs on gyrA and gyrBHypersusceptible to all 5 drugs, with MICs significantly lowered compared to H37Rv.GAT 0.12-0.5, MOX 0.12-0.25, LVX 0.25-1, OFX 0.25-1, and ENX 2-8 ug/ml.Proportion method14/150/4gyrA: Thr80Ala   
1327 Takiff HE AAC 1994 TCG/CCG27191Ser/ProPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
1338 Takiff HE AAC 1994 GAC/AAC28094Asp/AsnPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
1349 Takiff HE AAC 1994 GAC/CAC28094Asp/HisPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
13510 Bravao LTC JCM 2009 GAC/GTC280-28194Asp/PhePublished 2009PhillipinesSequencing225-bp gyrA QRDRHROfxN.S.Proportion method9/1021/0gyrA: Ser95Thr   
13611 Takiff HE AAC 1994 GAC/TAC28094Asp/TyrPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4602/542/0gyrA: Ser95Thr High confidence details 
13712 Takiff HE AAC 1994 GAC/GGC28194Asp/GlyPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 8BACTEC 4605/545/0gyrA: Ser95Thr High confidence details 
13813 Takiff HE AAC 1994 GAC/GCC28194Asp/AlaPublished 1994N.S.PCR-SSCP, Sequencing320-bp QRDR of gyrACIPCIP: 4BACTEC 4601/541/0gyrA: Ser95Thr High confidence details 
13914 Sulochana S J Chemother 2007 GAC/GTC28194Asp/ValPublished 2007IndiaSequencing320-bp gyrA QRDR, 360-bp gyrB QRDRModerately resistant to OFX.OFX: 16-64Absolute concentration method 71/1187/0gyrA: Ser95Thr   
14015 Kapur V Arch PathLabMEd 1995 AGC/ACC28495Ser/Thr             
14116 Kam KM Microb Drug Res 2006 CCC/CAC305102Pro/His           High confidence details 
14217 Sulochana S J Chemother 2007 CTG/GTG325109Leu/ValPublished 2007IndiaSequencing320-bp gyrA QRDR, 360-bp gyrB QRDRModerately susceptible to OFX.OFX: 2Absolute concentration method 71/1180/1    

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