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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0005

More about Rv0005 on    TBDB.org

More about Rv0005 on    TubercuList

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Codons 540 to 559:1 Mutation Codons 500 to 519:9 Mutation Codons 480 to 499:1 Mutation Codons 460 to 479:5 Mutation Codons 440 to 459:2 Mutation
Select interval to show only those mutations included. Selected interval is marked with a red color.
IDSeqNoAdded byPrimary referencePolymorphismNucleotide positionCodon positionAmino acidTime periodOriginMolecular detection methodGene coverageResistance patternMICSusceptibility testing methodR/Total isolatesR/S isolates with mutationAdditional mutationsEditDeleteHigh confidence supportSelect
1431 Feuerriegel S AAC 2009 CGT/TGT1369457Arg/Cys2003-2006UzbekistanSequencingQRDRs on gyrA and gyrBOFXN.S.BACTEC 460 and MGIT 96026/491/0    
1442 Duong DA AAC 2009 TCC/TTC1373458Ser/Phe2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0No other mutation in gyrA or gyrB   
1453 Duong DA AAC 2009 GAC/CAC1414472Asp/His2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0No other mutation in gyrA or gyrB   
1464 Aubry A AAC 2006 GAC/CAC1414472Asp/HisPublished 2006FranceSequencingQRDRs on gyrA and gyrBStrongly resistant to OFXOFX: 60ug/mlN.S.14/151/0Ala90Val in gyrA; no other mutations in QRDR of gyrB.   
1475 Pitaksajjakul P Southeast Asian J Trop Med Public Health 2005 GAC/AAC1414472Asp/AsnPublished 2005ThailandPCR-SSCP, Sequencing320-bp QRDR of gyrA; 429-bp QRDR of gyrB.INH+RIF+STR+EMB+OFX N.S.Absolute concentration method35/351/0No further mutations in gyrA or gyrB QRDRs found.   
1486 Duong DA AAC 2009 GAC/AAC1414472Asp/Asn2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0gyrA D94A   
1497 Duong DA AAC 2009 GAC/GCC1415472Asp/Ala2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0gyrA A90V   
1508 Duong DA AAC 2009 GGT/GCT1442481Gly/Ala2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0No other mutation in gyrA or gyrB   
1519 Lee AS Int J Infect Dis 2002 GAC/GCC1514505Asp/Ala             
15210 Aubry A AAC 2006 AAC/GAC1528510Asn/AspPublished 2006FranceSequencingQRDRs on gyrA and gyrBGAT, MOX, LVX, and OFX; strongly resistant to ENX.GAT: >1, MOX and LVX: 2, OFX: 4, and ENX: 64Proportion method14/151/0No other mutations in QRDR of gyrA or gyrB. High confidence details 
15311 Duong DA AAC 2009 AAC/ACC1529510Asn/Thr2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0gyrA A90V   
15412 Mokrousov I AAC 2008 AAC/AAA1530510Gln/Lys2004 - 2005TaiwanSequencingQRDRs on gyrA and gyrBOFX, CIP, LVX, and MOX. Out of the 14 FQ-R isolates, 6 (42.9%) were resistant to at least one 1st-line drug, while 4 (28.6%) were multidrug-resistant.OFX: 8, CIP: 5, LVX: 1, and MOX: 1Modified proportion method14/4201/0No further mutations in gyrA or gyrB QRDRs found.   
15513 Duong DA AAC 2009 ACC/CCC1531511Thr/Pro2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0gyrA A90V   
15614 Duong DA AAC 2009 GAA/GTA1535512Glu/Val2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0No other mutation in gyrA or gyrB   
15715 Duong DA AAC 2009 GAA/1536512Glu/Asp2005-2007VietnamSequencingQRDRs on gyrA and gyrB  Proportion method109/2181/0No other mutation in gyrA or gyrB   
15816 Mokrousov I AAC 2008 GCG/ACG1543515Ala/Thr2004 - 2005TaiwanSequencingQRDRs on gyrA and gyrBOFX, CIP, LVX, and MOX. Out of the 14 FQ-R isolates, 6 (42.9%) were resistant to at least one 1st-line drug, while 4 (28.6%) were multidrug-resistant.OFX: 8, CIP: 5, LVX: 1, and MOX: 1Modified proportion method14/4201/0No further mutations in gyrA or gyrB QRDRs found.   
15917 Mokrousov I AAC 2008 GCG/GTG1544515Ala/Val2004 - 2005TaiwanSequencingQRDRs on gyrA and gyrBOFX, CIP, LVX, and MOX. Out of the 14 FQ-R isolates, 6 (42.9%) were resistant to at least one 1st-line drug, while 4 (28.6%) were multidrug-resistant.OFX: 8, CIP: 5, LVX: 1, and MOX: 1Modified proportion method14/4201/0No further mutations in gyrA or gyrB QRDRs found.   
16018 Mokrousov I AAC 2008 CAA/CAT1647549Gln/His2004 - 2005TaiwanSequencingQRDRs on gyrA and gyrBOFX, CIP, LVX, and MOX. Out of the 14 FQ-R isolates, 6 (42.9%) were resistant to at least one 1st-line drug, while 4 (28.6%) were multidrug-resistant.OFX: 8, CIP: 5, LVX: 1, and MOX: 1Modified proportion method14/4201/0No further mutations in gyrA or gyrB QRDRs found.   

© 2010 Andreas Sandgren  |  Supported by The Swedish Research Council  |  Contact Database Curator