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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0006

More about Rv0006 on    TBDB.org

More about Rv0006 on    TubercuList

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Select interval to show only those mutations included. Selected interval is marked with a red color.
IDAdded byCountryTime periodSymbolGene IDMutationNo. of isolates testedNo. of isolates w/ mutationPercent tested w/ mutation Molecular detection method - gene coverageDST method - resistance pattern among R isolatesCommentsEditDeleteSelect
TotalRSRSRS
38 ChinaN.S.gyrARv0006D94G (GAC/GGC)75423315035.70%0.00%Sequencing, PCR-SSCP.QRDR of gyrAProportion method.All monoresistant    
49 RussiaN.S.gyrARv0006D94G (GAC/GGC)18567118101.50%0.00%Oligobased chip assay and sequencing.QRDR of gyrA Absolute concentration method.N.S    
125 Hong Kong1994-2004gyrARv0006D94G (GAC/GGC)2507117919026.80%0.00%PCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.69 MDR, 2 PDR    
259 Hong Kong1991-2000gyrARv0006D94G (GAC/GGC)138558311020.00%0.00%PCR-SSCP and sequencing.gyrA: 320bp fragmentAbsolute concentration and broth macrodilution methods.Among 138 isolates 92 were MDR, among these 55 were O resistant    
523 Hong Kong1999-2003gyrARv0006D94G (GAC/GGC)55352012034.30%0.00%Sequencing.QRDR of gyrAAbsolute concentration method and BACTEC MGIT 960.24 MDR, 11 O or PDR* Sequencing was preformed for isolates with OFL MIC >= 4 ug/ml, MIC <= 2ug/ml was defined as OFL sensitive   
542 SingaporeN.S.gyrARv0006D94G (GAC/GGC)1005347000.00%0.00%Sequencing.QRDR of gyrA and gyrBBACTEC 460 radiometric method.Resistant to at least one drug (H, R, S, E)    
721 Russia2006gyrARv0006D94G (GAC/GGC)70482219039.60%0.00%Sequencing.QRDR of gyrA and gyrBAbsolute concentration method.45 XDR, 3 MDR    
807 South Korea2004gyrARv0006D94G (GAC/GGC)73631021033.30%0.00%Sequencing.QRDR of gyrA and gyrBProportion method.All O resistant and different patterns of resistance to other FLQs    
985 China2002-2003gyrARv0006D94G (GAC/GGC) AG109872242148.30%4.50%DHPLC and Sequencing.gyrA: codon 74-95Absolute concentration method.Only information about O resistanceAG 10 isolates had both D94G and A74S mutations and 26 had both D94G and A90V mutations   
1005 India1995-1998gyrARv0006D94G (GAC/GGC)1286959202.90%0.00%Sequencing.gyrA: codon 89-95 and fragment of gyrBProportion method.18 O, 18 MDR, 33 PDR    
1188 IndiaN.S.gyrARv0006D94G (GAC/GGC)118724610013.90%0.00%Sequencing.QRDR of gyrA and gyrBAbsolute concentration method.38 O, 31 MDR, 2 PDR    
1266 Vietnam2005-2006gyrARv0006D94G (GAC/GGC)82424012028.60%0.00%Sequencing.QRDR of gyrA Proportion method.N.S    
1350 ChinaN.S.gyrARv0006D94G (GAC/GGC)68442416436.40%16.70%PCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.Only information about O resistance    

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