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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0006

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Select interval to show only those mutations included. Selected interval is marked with a red color.
IDAdded byCountryTime periodSymbolGene IDMutationNo. of isolates testedNo. of isolates w/ mutationPercent tested w/ mutation Molecular detection method - gene coverageDST method - resistance pattern among R isolatesCommentsEditDeleteSelect
TotalRSRSRS
43 ChinaN.S.gyrARv0006P102H (CCC/CAC)754233000.00%0.00%Sequencing, PCR-SSCP.QRDR of gyrAProportion method.All monoresistant    
54 RussiaN.S.gyrARv0006P102H (CCC/CAC) AP18567118000.00%5.00%Oligobased chip assay and sequencing.QRDR of gyrA Absolute concentration method.N.S    
130 Hong Kong1994-2004gyrARv0006P102H (CCC/CAC) AL25071179101.40%0.00%PCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.69 MDR, 2 PDRAL 1 Isolate had both A90V and P102H mutations.    
264 Hong Kong1991-2000gyrARv0006P102H (CCC/CAC)1385583000.00%0.00%PCR-SSCP and sequencing.gyrA: 320bp fragmentAbsolute concentration and broth macrodilution methods.Among 138 isolates 92 were MDR, among these 55 were O resistant    
528 Hong Kong1999-2003gyrARv0006P102H (CCC/CAC) AP553520215.70%5.00%Sequencing.QRDR of gyrAAbsolute concentration method and BACTEC MGIT 960.24 MDR, 11 O or PDR* Sequencing was preformed for isolates with OFL MIC >= 4 ug/ml, MIC <= 2ug/ml was defined as OFL sensitive. AP 2 isolates with both P102H and A90V mutations   
547 SingaporeN.S.gyrARv0006P102H (CCC/CAC)1005347000.00%0.00%Sequencing.QRDR of gyrA and gyrBBACTEC 460 radiometric method.Resistant to at least one drug (H, R, S, E)    
726 Russia2006gyrARv0006P102H (CCC/CAC) AP704822000.00%5.00%Sequencing.QRDR of gyrA and gyrBAbsolute concentration method.45 XDR, 3 MDR    
812 South Korea2004gyrARv0006P102H (CCC/CAC)736310000.00%0.00%Sequencing.QRDR of gyrA and gyrBProportion method.All O resistant and different patterns of resistance to other FLQs    
990 China2002-2003gyrARv0006P102H (CCC/CAC)1098722000.00%0.00%DHPLC and Sequencing.gyrA: codon 74-95Absolute concentration method.Only information about O resistance    
1010 India1995-1998gyrARv0006P102H (CCC/CAC)1286959000.00%0.00%Sequencing.gyrA: codon 89-95 and fragment of gyrBProportion method.18 O, 18 MDR, 33 PDR    
1193 IndiaN.S.gyrARv0006P102H (CCC/CAC)1187246000.00%0.00%Sequencing.QRDR of gyrA and gyrBAbsolute concentration method.38 O, 31 MDR, 2 PDR    
1260 Vietnam2005-2006gyrARv0006P102H (CCC/CAC) AP824240000.00%5.00%Sequencing.QRDR of gyrA Proportion method.N.S    
1355 ChinaN.S.gyrARv0006P102H (CCC/CAC)684424000.00%0.00%PCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.Only information about O resistance    

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