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FLUOROQUINOLONES [FLQ]


gyrB: Rv0005gyrA: Rv0006

Rv0005

More about Rv0005 on    TBDB.org

More about Rv0005 on    TubercuList

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Select interval to show only those mutations included. Selected interval is marked with a red color.
IDAdded byCountryTime periodSymbolGene IDMutationNo. of isolates testedNo. of isolates w/ mutationPercent tested w/ mutation Molecular detection method - gene coverageDST method - resistance pattern among R isolatesCommentsEditDeleteSelect
TotalRSRSRS
45 ChinaN.S.gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/ASequencing, PCR-SSCP.QRDR of gyrAProportion method.All monoresistant    
56 RussiaN.S.gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/AOligobased chip assay and sequencing.QRDR of gyrA Absolute concentration method.N.S    
132 Hong Kong1994-2004gyrBRv0005N538D (AAC/GAC)*N/AN/AN/AN/AN/AN/AN/APCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.69 MDR, 2 PDR    
266 Hong Kong1991-2000gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/APCR-SSCP and sequencing.gyrA: 320bp fragmentAbsolute concentration and broth macrodilution methods.Among 138 isolates 92 were MDR, among these 55 were O resistant    
530 Hong Kong1999-2003gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/ASequencing.QRDR of gyrAAbsolute concentration method and BACTEC MGIT 960.24 MDR, 11 O or PDR* Sequencing was preformed for isolates with OFL MIC >= 4 ug/ml, MIC <= 2ug/ml was defined as OFL sensitive   
549 SingaporeN.S.gyrBRv0005N538D (AAC/GAC)1005347000.00%0.00%Sequencing.QRDR of gyrA and gyrBBACTEC 460 radiometric method.Resistant to at least one drug (H, R, S, E)    
728 Russia2006gyrBRv0005N538D (AAC/GAC)704822000.00%N/ASequencing.QRDR of gyrA and gyrBAbsolute concentration method.45 XDR, 3 MDR    
814 South Korea2004gyrBRv0005N538D (AAC/GAC)736310000.00%0.00%Sequencing.QRDR of gyrA and gyrBProportion method.All O resistant and different patterns of resistance to other FLQs    
992 China2002-2003gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/ADHPLC and Sequencing.gyrA: codon 74-95Absolute concentration method.Only information about O resistance    
1012 India1995-1998gyrBRv0005N538D (AAC/GAC)1286959000.00%0.00%Sequencing.gyrA: codon 89-95 and fragment of gyrBProportion method.18 O, 18 MDR, 33 PDR    
1184 IndiaN.S.gyrBRv0005N538D (AAC/GAC) AJ118724600N/AN/ASequencing.QRDR of gyrA and gyrBAbsolute concentration method.38 O, 31 MDR, 2 PDRAJ Only 2 OFL resistant isolates without gyrA mutations were screened for gyrB mutations   
1262 Vietnam2005-2006gyrBRv0005N538D (AAC/GAC)824240N/AN/AN/AN/ASequencing.QRDR of gyrA Proportion method.N.S    
1357 ChinaN.S.gyrBRv0005N538D (AAC/GAC)N/AN/AN/AN/AN/AN/AN/APCR-SSCP and Sequencing.QRDR of gyrAAbsolute concentration method.Only information about O resistance    

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